DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and ABL2

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens

Alignment Length:	566	Identity:	195/566 - (34%)
Similarity:	284/566 - (50%)	Gaps:	73/566 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   501 QQQASHSILSTFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGG------A 559
            ||.....|..:.|..|:.....|||..:..|.....       |..|   .|:|...|      .
Human    15 QQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFT-------QHDH---FASCVEDGFEGDKTG 69

  Fly   560 GLMSSSLNAAQMGMHGAERALPPKSL--ALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSA 622
            |....:|:..    :|.:  :.|::|  |:..|.. .|:|..|...|
Human    70 GSSPEALHRP----YGCD--VEPQALNEAIRWSSK-ENLLGATESDP------------------ 109

  Fly   623 GMSTSLHSFDING-----VTAGS-----GVNASSAWSSGSTTAMNHASLSPT-ALAPQQGRSRCE 676
            .:..:|:.|..:|     :|.|.     |.|.:..||  ...:.|.....|: .:.|..
Human   110 NLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWS--EVRSKNGQGWVPSNYITPVN------ 166

  Fly   677 VKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVK-YLENKL 740
             .|....|:||.::|..||:||....:|.||||||.:.||..::.:.::.:|.|||:. ..:.|:
Human   167 -SLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 230

  Fly   741 TIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRES 805
            .:..|..|..|.:||.|:...||||.|.|....||..|.  .:.....:...|.:...::.::..
Human   231 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKP--TVYGVSPIHDKWEMERTDITMKHK 293

  Fly   806 IGKGEFGDVMLGILRNEK--VAVKMLK-DEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLY 867
            :|.|::|:|.:|:.:...  ||||.|| |...|::||.||:||..::|.|||:.:|:.......|
Human   294 LGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFY 358

  Fly   868 LVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVA 932
            :|||||..|:|:||||...|:.:|....:..|...:|.|||||.|..:||||||||.|:.|:.|.
Human   359 IVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVV 423

  Fly   933 KVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPR 993
            ||:||||:|   .:.|....| |.||||||||:|....||.|||:|:||:|||||.::|..|||.
Human   424 KVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPG 488

  Fly   994 IPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAE 1039
            |.|:.|...:|.||:||.||||||::||:||..|..:||.||:|||
Human   489 IDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	36/97 (37%)
		PTKc_Csk_like	793..1047	CDD:270635	120/254 (47%)
		STYKc	800..1044	CDD:214568	119/247 (48%)
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		9/31 (29%)
		CAP	2..106		23/107 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80		3/23 (13%)
		SH3_Abl	111..164	CDD:212784	11/54 (20%)
		SH2_ABL	169..262	CDD:198189	34/92 (37%)
		PTKc_Abl	281..543	CDD:270645	120/254 (47%)
		Pkinase_Tyr	288..539	CDD:285015	119/247 (48%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		10/23 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910