DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csk and csk-1

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001293162.1	Gene:	csk-1 / 266817	WormBaseID:	WBGene00000812	Length:	624	Species:	Caenorhabditis elegans

Alignment Length:	656	Identity:	251/656 - (38%)
Similarity:	368/656 - (56%)	Gaps:	93/656 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   442 HHRENNVHPIQAGAAAALHLSSHAL--NSHNLISSASNHSPKSP-SQTQQQQQTTNQQQQQQQQQ 503
            ||| |:.:|.:        .|:.::  .||:|..|:|  ||.|. |...:.....|:.:..:|:.
Worm    12 HHR-NSRNPTK--------FSNFSIEKRSHSLGGSSS--SPTSSFSSNDEFDDRQNKNKFWRQRN 65

  Fly   504 ASHS----ILSTFAPAPTVAAVQPAGS-----QSVAGTAAAVAAVAQQQQQQHLQLLAN---CPP 556
            .|::    |:..|. |..:..:....|     |.......:.::.:.|.|.:...|.||   ..|
Worm    66 VSNAEIERIIEDFI-ANGILKMSNGNSYNHHHQFPMSIPISCSSHSIQSQSRMNTLNANRDLLSP 129

  Fly   557 GGAGLMSSSLNAAQMGMHGAERALPPKSLALSGSQHGSNMLLHTAP---QPPQASQPA------A 612
            |...:::.:::.: ...||    :|.:........|...:...|.|   :...|:|..      .
Worm   130 GNDVIVTRTVSPS-FYSHG----MPARDNVFRKDDHVRILGNTTDPAWYRARNANQEEGLVHADC 189

  Fly   613 VVGVSGSGSAGMSTSLHSFDINGVT--AGSGVN-ASSAWSSGSTTAMNHASLSPTALAPQQGRSR 674
            ||.::|          .::| ||:.  ..||.: |..|.|:.|:|:.:|::.:
Worm   190 VVRING----------QAYD-NGIVRMRASGCDVAPGAASTTSSTSSHHSTAA------------ 231

  Fly   675 CEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLE-N 738
                 |..||||..|:|:..|.||:.:.||.||||||||||||:|||:.|..||||||::... .
Worm   232 -----NHQPWFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMSFHGKVEHYRIEQTSGG 291

  Fly   739 KLTIDDEEYFENLGQLVAHYEADADGLCTQLIK---C----LPKLGKQEFCINSK-DFVDK---- 791
            :||.|.||||.||.|||:||:.||||||.:|:.   |    ....|...|..:|. |..|:
Worm   292 QLTCDKEEYFSNLTQLVSHYKRDADGLCHRLVTPIICETATFSSNGSSSFGSSSTVDLEDRTSVF 356

  Fly   792 ---GWVIPEAELQLRESIGKGEFGDVMLGILRNEKVAVKMLK--DEGAVQKFLAEASVMTTLEHD 851
               |.||...::.:.::||.||||||.||..:|.|||:|:.|  ..|.:...|.||..|..|.|.
Worm   357 RHAGLVISSNDIDVGDTIGHGEFGDVRLGTYKNRKVALKVSKRHGNGMLDSLLDEAKFMVGLSHP 421

  Fly   852 NLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVH 916
            |||..:|:|....::|::||||:.|:|:|.||||||..:.::..::||.|...||.|||:|::||
Worm   422 NLVTLVGVVLDDVNVYMITEYMANGNLIDLLRSRGRHALERRQLMMFAMDICQGMCYLESKQIVH 486

  Fly   917 RDLAARNVLISEDCVAKVSDFGLARE---ECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGI 978
            |||||||||:.:|.||||||||||::   :.::...||.||||||||||::.:|:.|||:|||||
Worm   487 RDLAARNVLLDDDLVAKVSDFGLAKKANSQSHDSASGKFPIKWTAPEALRHSQFTTKSDVWSFGI 551

  Fly   979 LLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVK 1043
            |||||:|||||||||||:.|||:::|.||:|||||||||||:::|.:.|.|:...||:|.::..:
Worm   552 LLWEIFSFGRVPYPRIPIQDVVRYIEKGYRMEAPEGCPPEIFKVMNETWALSAQDRPSFGQVLQR 616

  Fly  1044 LQLLNN 1049
            |..:.|
Worm   617 LTTIRN 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	56/104 (54%)
		PTKc_Csk_like	793..1047	CDD:270635	136/258 (53%)
		STYKc	800..1044	CDD:214568	133/248 (54%)
csk-1	NP_001293162.1	SH2_csk_like	232..330	CDD:198190	56/97 (58%)
		PTKc_Csk_like	362..620	CDD:270635	136/257 (53%)
		STYKc	368..617	CDD:214568	133/248 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159721
Domainoid	1	1.000	282	1.000	Domainoid score	I870
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55818
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto20058
orthoMCL	1	0.900	-	-		OOG6_107422
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3150
SonicParanoid	1	1.000	-	-		X2621
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.770