DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Csk and Hck

DIOPT Version :9

Sequence 1:NP_001262476.1 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_037317.2 Gene:Hck / 25734 RGDID:2785 Length:524 Species:Rattus norvegicus


Alignment Length:538 Identity:182/538 - (33%)
Similarity:274/538 - (50%) Gaps:73/538 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   554 CPPGGA---------------GLMSSSL--NAAQMGMHGAERALPPKSLALSGSQHGSNMLLHTA 601
            ||.|..               |..:|.:  ||.|.|.........||.|       |.|.:....
  Rat    12 CPRGEGRVPRMGCVKSRFLREGSKASKIEPNANQKGPVYVPDPTSPKKL-------GPNSINSLP 69

  Fly   602 PQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGV--NASSAWSSGSTTAMNHASLSPT 664
            |...:.|:...||.:..      ..::|..|::.......|  ..|..|....:.|.......| 
  Rat    70 PGVVEGSEDTIVVALYD------YEAIHREDLSFQKGDQMVVLEESGEWWKARSLATKKEGYIP- 127

  Fly   665 ALAPQQGRSRCEVKLNAM---PWFHGSITRDEAE-HLLQPRED-GLFLVRESTNFPGDYTLCV-C 723
                    |....::|::   .||...|:|.:|| |||.|... |.|::|:|....|.|:|.| .
  Rat   128 --------SNYVARVNSLETEEWFFKGISRKDAERHLLAPGNMLGSFMIRDSETTKGSYSLSVRD 184

  Fly   724 FQSK----VEHYRVKYLEN-KLTIDDEEYFENLGQLVAHYEADADGLCTQL-IKCL-PKLGKQEF 781
            |..:    |:||:::.|:: ...|.....|.:|.:||.||:...||||.:| :.|: ||      
  Rat   185 FDPQHGDTVKHYKIRTLDSGGFYISPRSTFSSLQELVVHYKKGKDGLCQKLSVPCVSPK------ 243

  Fly   782 CINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGIL-RNEKVAVKMLKDEG-AVQKFLAEASV 844
              ..|.:....|.||...||:.:.:|.|:||:|.:... ::.|||||.:|... :|:.|||||::
  Rat   244 --PQKPWEKDAWEIPRESLQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANL 306

  Fly   845 MTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSR--GRQHITKKDQIIFAYDTASGME 907
            |.||:||.||| :..|.:.:.:::|||:|:||||:|:|:|.  .:|.:.|  .|.|:...:.||.
  Rat   307 MKTLQHDKLVK-LHAVVSQEPIFIVTEFMAKGSLLDFLKSEEGSKQPLPK--LIDFSAQISEGMA 368

  Fly   908 YLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFS 968
            ::|.:..:||||.|.|:|:|...|.|::||||||   :..|....| |.|||||||||:..|.|:
  Rat   369 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFT 433

  Fly   969 NKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAK 1033
            .|||:|||||||.||.::||:|||.:...:|::.:|.||:|..|:.||.|:|.:|.:.|...|.:
  Rat   434 IKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPDNCPEELYSIMIRCWKNRPEE 498

  Fly  1034 RPTFAELKVKLQLLNNAT 1051
            ||||..::..|.....||
  Rat   499 RPTFEYIQSVLDDFYTAT 516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CskNP_001262476.1 SH2_csk_like 680..777 CDD:198190 39/109 (36%)
PTKc_Csk_like 793..1047 CDD:270635 114/261 (44%)
STYKc 800..1044 CDD:214568 110/251 (44%)
HckNP_037317.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 3/7 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..71 10/42 (24%)
SH3 80..135 CDD:302595 10/69 (14%)
SH2_Src_HCK 138..241 CDD:198226 36/102 (35%)
PKc_like 252..522 CDD:304357 116/268 (43%)
Pkinase_Tyr 260..509 CDD:285015 110/251 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D248674at33208
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.820

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