DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csk and Fyn

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_006256584.1	Gene:	Fyn / 25150	RGDID:	2641	Length:	575	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	180/532 - (33%)
Similarity:	260/532 - (48%)	Gaps:	98/532 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   588 SGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNASSA----- 647
            ||.::|      |.|.|    |.....||:   |.....:.|:....|:|...|||:||.
  Rat    64 SGYRYG------TDPTP----QHYPSFGVT---SIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLR 115

  Fly   648 ------------------------------------------WSSGSTTAMNHASLSPTALAPQQ 670
                                                      |.:.|.|......:....:||..
  Rat   116 TRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVD 180

  Fly   671 GRSRCEVKLNAMPWFHGSITRDEAEHLL----QPREDGLFLVRESTNFPGDYTLCV-----CFQS 726
                   .:.|..|:.|.:.|.:||..|    .||  |.||:|||....|.|:|.:     ....
  Rat   181 -------SIQAEEWYFGKLGRKDAERQLLSFGNPR--GTFLIRESETTKGAYSLSIRDWDDMKGD 236

  Fly   727 KVEHYRVKYLEN-KLTIDDEEYFENLGQLVAHYEADADGLCTQLI----KCLPKLGKQEFCINSK 786
            .|:||:::.|:| ...|.....||.|.|||.||...|.|||.:|:    |.:|:|  .:..:.:|
  Rat   237 HVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRL--TDLSVKTK 299

  Fly   787 DFVDKGWVIPEAELQLRESIGKGEFGDVMLGILR-NEKVAVKMLKDEGAV--QKFLAEASVMTTL 848
            |.    |.||...|||.:.:|.|:||:|.:|... |.|||:|.|| .|.:  :.||.||.:|..|
  Rat   300 DV----WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLK-PGTMSPESFLEEAQIMKKL 359

  Fly   849 EHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKK 913
            :||.||:...:| :.:.:|:|||||:||||:|:|:....:.:...:.:..|...|:||.|:|...
  Rat   360 KHDKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN 423

  Fly   914 VVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMW 974
            .:||||.:.|:|:....:.|::||||||   :..|....| |.|||||||||...|||:.|||:|
  Rat   424 YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 488

  Fly   975 SFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAE 1039
            ||||||.|:.:.||||||.:...:|::.||.||:|..|:.||..::|:|...|..:|.:||||..
  Rat   489 SFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEY 553

  Fly  1040 LKVKLQLLNNAT 1051
            |:..|:....||
  Rat   554 LQGFLEDYFTAT 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	39/110 (35%)
		PTKc_Csk_like	793..1047	CDD:270635	113/260 (43%)
		STYKc	800..1044	CDD:214568	109/250 (44%)
Fyn	XP_006256584.1	SH3_Fyn_Yrk	123..178	CDD:212939	3/54 (6%)
		SH2_Src_Fyn_isoform_a_like	183..283	CDD:198281	37/101 (37%)
		PTKc_Fyn	299..572	CDD:270655	117/273 (43%)
		Pkinase_Tyr	309..558	CDD:285015	109/250 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820