DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and ABL1

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_009297.2	Gene:	ABL1 / 25	HGNCID:	76	Length:	1149	Species:	Homo sapiens

Alignment Length:	491	Identity:	183/491 - (37%)
Similarity:	268/491 - (54%)	Gaps:	44/491 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   583 KSLALSGSQHGSNMLLHTAPQPPQAS--QPAAVVGVSGSGS-----AGMS-------TSLHSFDI 633
            |..:..|..|.:..:.|.|.|.|.||  :|..:...:...|     ||.|       .:|:.|..
Human    29 KESSRHGGPHCNVFVEHEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVA 93

  Fly   634 NG-----VTAGS-----GVNASSAWSSGSTTAMNHASLSPT-ALAPQQGRSRCEVKLNAMPWFHG 687
            :|     :|.|.     |.|.:..|....|  .|.....|: .:.|..       .|....|:||
Human    94 SGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYITPVN-------SLEKHSWYHG 149

  Fly   688 SITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYL-ENKLTIDDEEYFENL 751
            .::|:.||:||....:|.||||||.:.||..::.:.::.:|.|||:... :.||.:..|..|..|
Human   150 PVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTL 214

  Fly   752 GQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVML 816
            .:||.|:...||||.|.|....||..|......|.:: || |.:...::.::..:|.|::|:|..
Human   215 AELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNY-DK-WEMERTDITMKHKLGGGQYGEVYE 277

  Fly   817 GILRNEK--VAVKMLK-DEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSL 878
            |:.:...  ||||.|| |...|::||.||:||..::|.|||:.:|:.......|::||:|:.|:|
Human   278 GVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNL 342

  Fly   879 VDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR-- 941
            :||||...||.:.....:..|...:|.|||||.|..:||||||||.|:.|:.:.||:||||:|
Human   343 LDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM 407

  Fly   942 -EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVE 1004
             .:.|....| |.||||||||:|...:||.|||:|:||:|||||.::|..|||.|.|:.|.:.:|
Human   408 TGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE 472

  Fly  1005 VGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            ..|:||.|||||.::||:||..|..||:.||:|||:
Human   473 KDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEI 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	37/97 (38%)
		PTKc_Csk_like	793..1047	CDD:270635	115/255 (45%)
		STYKc	800..1044	CDD:214568	114/248 (46%)
ABL1	NP_009297.2	SH3_Abl	84..137	CDD:212784	11/54 (20%)
		SH2_ABL	142..235	CDD:198189	35/92 (38%)
		PTKc_Abl	254..516	CDD:270645	115/255 (45%)
		Pkinase_Tyr	261..512	CDD:285015	114/248 (46%)
		FABD	1025..1149	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910