DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csk and Yes1

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_006245737.1	Gene:	Yes1 / 24884	RGDID:	3977	Length:	541	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	180/530 - (33%)
Similarity:	256/530 - (48%)	Gaps:	78/530 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   572 GMHGAERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMS---------TS 627
            |.:|.|.|....:.:..|:....|.|..|   |...|.     ||:..|.|..|         ||
  Rat    30 GHYGVEHATAATTSSTKGASANFNSLSMT---PFGGSS-----GVTPFGGASSSFSVVPSSYPTS 86

  Fly   628 L--------------------------HSFDINGVTAGSGVNASSAWSSGSTTAMNHASLSPTAL 666
            |                          ..|.|...|.|..      |.:.|.....:..:....:
  Rat    87 LTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDW------WEARSIATGKNGYIPSNYV 145

  Fly   667 APQQGRSRCEVKLNAMPWFHGSITRDEAEH-LLQP-REDGLFLVRESTNFPGDYTLCV-----CF 724
            ||..       .:.|..|:.|.:.|.:||. ||.| .:.|:||||||....|.|:|.:     ..
  Rat   146 APAD-------SIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVR 203

  Fly   725 QSKVEHYRVKYLEN-KLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDF 788
            ...|:||:::.|:| ...|.....|:.|.:||.||...|||||.:|....|.:..|     ::..
  Rat   204 GDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQ-----TQGL 263

  Fly   789 VDKGWVIPEAELQLRESIGKGEFGDVMLGILR-NEKVAVKMLKDEGAV--QKFLAEASVMTTLEH 850
            ....|.||...|:|...:|:|.||:|.:|... ..|||:|.|| .|.:  :.||.||.:|..|.|
  Rat   264 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLK-PGTMMPEAFLQEAQIMKKLRH 327

  Fly   851 DNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVV 915
            |.||....:| :.:.:|:|||:||||||:|:|:....:::.....:..|...|.||.|:|....:
  Rat   328 DKLVPLYAVV-SEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYI 391

  Fly   916 HRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSF 976
            ||||.|.|:|:.|:.|.|::||||||   :..|....| |.|||||||||...|||:.|||:|||
  Rat   392 HRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 456

  Fly   977 GILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELK 1041
            |||..|:.:.||||||.:...:|::.||.||:|..|:|||..::|:|...|..:|.:||||..::
  Rat   457 GILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQ 521

  Fly  1042 VKLQLLNNAT 1051
            ..|:....||
  Rat   522 SFLEDYFTAT 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	38/104 (37%)
		PTKc_Csk_like	793..1047	CDD:270635	113/260 (43%)
		STYKc	800..1044	CDD:214568	109/250 (44%)
Yes1	XP_006245737.1	SH3_Yes	92..149	CDD:212940	8/62 (13%)
		SH2_Src_family	152..251	CDD:199827	37/98 (38%)
		PTKc_Yes	262..540	CDD:270654	115/272 (42%)
		Pkinase_Tyr	275..524	CDD:285015	109/250 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920