Protein Alignment Csk and Ret

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_036775.2
• Gene: Ret / 24716
• RGDID: 3556
• Length: 1115
• Species: Rattus norvegicus
• Alignment Length: 928
• Identity: 212/928 - (22%)
• Similarity: 317/928 - (34%)
• Gaps: 288/928 - (31%)

  Fly   262 SEEW-FDEEAQARKTSHEKSQKPKPKPEENHKEKEAISRKAS--GEGDLITVEIKQGLLRKQTAT 323
            |..| .|.|.|.:.....:.....|..   :|||.|:|...:  .|.|             ...|
  Rat   224 STRWALDRELQEKYVLEAECAVAGPGA---NKEKVAVSFPVTVYDEDD-------------SPPT 272

  Fly   324 TTTGQAMNSHATATQNGQTTVVGHHRGFSQPSVTVAAAAATGST----AGDPWFLQTTGHQMPPT 384
            .:.|....|.....:..:.|||...:.|....|..:.......|    :||.|..||...:..|.
  Rat   273 FSGGVGTASAVVEFKRKEGTVVATLQVFDADVVPASGELVRRYTSTLLSGDSWAQQTFRVEHTPN 337

  Fly   385 APL---RHNKRPAPQPN-------------------AVLGAGSSGTAPGSAVGAVLLHQQQLSQS 427
            ..|   .:|...|...|                   .||...|....|||  |.:.||      .
  Rat   338 ETLVQSNNNSVRATMHNYKLVLNRSLSISESRVLQLVVLVNDSDFQGPGS--GVLFLH------F 394

  Fly   428 QPHIVPPSIPPHHHHHRENNV-----HPIQAGAAAALHLSSHALNSHNLISSASNHSPKSPSQTQ 487
            ...::|.::          |:     .|:...|.....:....:.:....|..|......||.|
  Rat   395 NVSVLPVTL----------NLPMAYSFPVNRRARRYAQIGKVCVENCQEFSGVSIQYKLQPSST- 448

  Fly   488 QQQQTTNQQQQQQQQQASHSILSTFAPAPTVAAVQPAGSQSVAGTAA-----------AVAAVAQ 541
                                  :..|.....:....:|:..|..|.|           .|.|..:
  Rat   449 ----------------------NCSALGVVTSTEDTSGTLYVNDTEALRRPECTELQYTVVATDR 491

  Fly   542 QQQQQHLQLLANCPPGGAGLMSSSLNAAQMGMHGAERALPPKSLALSGSQHGSNMLLHTAPQPPQ 606
            |.::|               ..:||.....|.:.||....|||.|::             .:.|:
  Rat   492 QTRRQ---------------TQASLVVTVEGTYIAEEVGCPKSCAVN-------------KRRPE 528

  Fly   607 ASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNASSAWSSGSTTAMNHASLSPTALAPQQG 671
            ..:      ..|.||..........|..|:|                  .|.::.||:......|
  Rat   529 CEE------CGGLGSPTGRCEWRQGDGKGIT------------------RNFSTCSPSTRTCPDG 569

  Fly   672 RSRCEV----KLNAMP--WFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEH 730
              .|:.    .:|..|  ...|.|        :...|.|     |.......|.:|.||..
  Rat   570 --HCDALESRDINICPQDCLRGPI--------VGGHERG-----ERQGIKAGYGICNCFPD---- 615

  Fly   731 YRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIK----------------CL------ 773
                  |.|...:.|   ::.|.|       .|.||..:|.                |:
  Rat   616 ------EKKCFCEPE---DSQGPL-------CDELCRTVITAAVLFSFIISVLLSTFCIHRYHKH 664

  Fly   774 ---PKLGKQE--FCINSKDF-----------------------------VDKGWVIPEAELQLRE 804
               |.:...|  ||..::.|                             .|..|..|...|.|.:
  Rat   665 AHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSMENQVSVDSFKIPEDPKWEFPRKNLVLGK 729

  Fly   805 SIGKGEFGDV-------MLGILRNEKVAVKMLKD---EGAVQKFLAEASVMTTLEHDNLVKFIGL 859
            ::|:||||.|       :.|......|||||||:   :..::..|:|.:::..:.|.:::|..|.
  Rat   730 TLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIKLYGA 794

  Fly   860 VFTSKHLYLVTEYMSKGSLVDYLR-----------------SRGRQH-----ITKKDQIIFAYDT 902
            ......|.|:.||...|||..:||                 |....|     :|..|.|.||:..
  Rat   795 CSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSSGGSRNSSSLDHPDERVLTMGDLISFAWQI 859

  Fly   903 ASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR----EECY-NLDVGKLPIKWTAPEAL 962
            :.||:||...|:|||||||||:|::|....|:|||||:|    |:.| ....|::|:||.|.|:|
  Rat   860 SRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIESL 924

  Fly   963 KNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAW 1027
            .:..::.:||:||||:|||||.:.|..|||.||...:...::.|::||.|:.|..|:|.:|.|.|
  Rat   925 FDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCW 989

  Fly  1028 DLNPAKRPTFAELKVKLQ 1045
            ...|.|||.||::...|:
  Rat   990 KQEPDKRPVFADISKDLE 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	22/123 (18%)
		PTKc_Csk_like	793..1047	CDD:270635	105/290 (36%)
Ret	NP_036775.2	RET_CLD1	29..154	CDD:465485
		Cadherin-like region 1 (CLD1). /evidence=ECO:0000250|UniProtKB:P07949	29..153
		Cadherin	173..248	CDD:394985	5/23 (22%)
		Cadherin-like region 3 (CLD3). /evidence=ECO:0000250|UniProtKB:P07949	266..380		23/126 (18%)
		RET_CLD3	266..380	CDD:465516	23/126 (18%)
		Cadherin-like region 4 (CLD4). /evidence=ECO:0000250|UniProtKB:P07949	406..507		18/138 (13%)
		RET_CLD4	408..507	CDD:465517	18/136 (13%)
		PTKc_RET	724..1013	CDD:173631	103/284 (36%)