DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and FRK

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_002022.1	Gene:	FRK / 2444	HGNCID:	3955	Length:	505	Species:	Homo sapiens

Alignment Length:	382	Identity:	154/382 - (40%)
Similarity:	225/382 - (58%)	Gaps:	19/382 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   679 LNAMPWFHGSITRDEAEH--LLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYL-ENKL 740
            |.|.|||.|:|.|.:||.  |....:.|.||:|||.:..|:::|.|...:.|:|||:|.| |...
Human   111 LQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGF 175

  Fly   741 TIDDEEYFENLGQLVAHYEADADGLCTQLIK-CLPKLGKQEFCINSKDFVDKGWVIPEAELQLRE 804
            .:.....|..|.:.|:||...:||||.:|.| ||.......|.::.|. ||: |.|....:||.:
Human   176 FLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKT-VDQ-WEIDRNSIQLLK 238

  Fly   805 SIGKGEFGDVMLGILRN-EKVAVKMLKDEGAV--QKFLAEASVMTTLEHDNLVKFIGLVFTSKHL 866
            .:|.|:||:|..|:..| ..||||.|| .|::  ..||.||.:|..|.|..|::...:......:
Human   239 RLGSGQFGEVWEGLWNNTTPVAVKTLK-PGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPI 302

  Fly   867 YLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCV 931
            |::||.|..|||.:||::.....|....|:..|...||||.|||::..:||||||||||:.|..:
Human   303 YIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNI 367

  Fly   932 AKVSDFGLAR------EECYNL--DVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGR 988
            .||:||||||      |:.|..  :: |||:|||||||:::.:||.|||:|||||||:||.::|:
Human   368 YKVADFGLARVFKVDNEDIYESRHEI-KLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGK 431

  Fly   989 VPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQ 1045
            :||..:..|.|::.:...|::..|..||.:.|.:|.:.|:..|.:||||..|:.||:
Human   432 MPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLE 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	39/100 (39%)
		PTKc_Csk_like	793..1047	CDD:270635	110/264 (42%)
		STYKc	800..1044	CDD:214568	106/254 (42%)
FRK	NP_002022.1	SH3_Src_like	47..104	CDD:212779
		SH2_Src_Frk	112..207	CDD:199831	36/94 (38%)
		PTKc_Frk_like	225..494	CDD:270653	111/267 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820