DRSC/TRiP Functional Genomics Resources

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Protein Alignment Csk and FGFR3

DIOPT Version :10

Sequence 1:NP_731611.2 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster
Sequence 2:XP_006713931.1 Gene:FGFR3 / 2261 HGNCID:3690 Length:811 Species:Homo sapiens


Alignment Length:766 Identity:197/766 - (25%)
Similarity:307/766 - (40%) Gaps:234/766 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   513 APA------PTVAAVQPAGSQS------VAGTAAAVAAVAQQQQQQHL-----QLLANCPPGGAG 560
            |||      ..||.|..|.|:|      |.|.||.|......||:|.:     .:..:|||.|.|
Human     3 APACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGG 67

  Fly   561 LMSSSLNAAQ-MGMHGAERAL--PPKSLALSGSQHGS-----------NMLLH------------ 599
            .|..::.... .|:..:||.|  |.:...|:.|...|           .:|.|            
Human    68 PMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSG 132

  Fly   600 ---------------------TAPQ--------PPQASQ-----PAAVVGVSGSGSAGMSTSLHS 630
                                 |.|:        .|.|:.     |||     |:.:..:|...:.
Human   133 DDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAA-----GNPTPSISWLKNG 192

  Fly   631 FDINGVTAGSGVN-ASSAWS---------------------SGS---TTAMNHASLSP------- 663
            .:..|.....|:. ....||                     .||   |..::....||       
Human   193 REFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQA 257

  Fly   664 ------TALAPQQGRSRCEVKLNAMP----------------------------WFHGSITRDEA 694
                  ||:........|:|..:|.|                            |...|:..|..
Human   258 GLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISESVEADVR 322

  Fly   695 EHL--LQPREDGLFLVRESTNFPG--------------------------------------DYT 719
            ..|  :..|:.|.:|.| :|||.|                                      .:.
Human   323 LRLANVSERDGGEYLCR-ATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFF 386

  Fly   720 LCVCFQSKVEHYRVKYLENK----LTIDDEEYFENLGQLVAHYEADAD-GLCTQLIKCLPKL--G 777
            |.:...:.|...|::....|    .|:.....|....|:....|::|. ...|.|:: :.:|  |
Human   387 LFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVTVSLESNASMSSNTPLVR-IARLSSG 450

  Fly   778 KQEFCINSKDF---VDKGWVIPEAELQLRESIGKGEFGDVM----LGILRNE-----KVAVKMLK 830
            :.....|..:.   .|..|.:..|.|.|.:.:|:|.||.|:    :||.::.     .|||||||
Human   451 EGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLK 515

  Fly   831 DEGA---VQKFLAEASVMTTL-EHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSR------ 885
            |:..   :...::|..:|..: :|.|::..:|.......||::.||.:||:|.::||:|      
Human   516 DDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLD 580

  Fly   886 --------GRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLARE 942
                    ..:.:|.||.:..||..|.|||||.::|.:||||||||||::||.|.|::|||||| 
Human   581 YSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLAR- 644

  Fly   943 ECYNLDV------GKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVK 1001
            :.:|||.      |:||:||.|||||.:..::::||:||||:|||||::.|..|||.||:.::.|
Human   645 DVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFK 709

  Fly  1002 HVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLLNNATA 1052
            .::.|::|:.|..|..::|.:||:.|...|::||||.:|...|..:...|:
Human   710 LLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTS 760

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CskNP_731611.2 SH2_csk_like 680..777 CDD:198190 26/171 (15%)
PTKc_Csk_like 793..1047 CDD:270635 112/286 (39%)
FGFR3XP_006713931.1 Ig 37..109 CDD:472250 18/71 (25%)
Ig strand B 57..61 CDD:409362 0/3 (0%)
Ig strand C 69..75 CDD:409362 1/5 (20%)
Ig strand E 92..96 CDD:409362 0/3 (0%)
IgI_2_FGFR 151..245 CDD:409443 16/98 (16%)
Ig strand A 151..154 CDD:409443 0/2 (0%)
Ig strand A' 162..167 CDD:409443 0/4 (0%)
Ig strand B 171..179 CDD:409443 1/7 (14%)
Ig strand C 185..190 CDD:409443 1/4 (25%)
Ig strand C' 193..195 CDD:409443 0/1 (0%)
Ig strand D 204..207 CDD:409443 0/2 (0%)
Ig strand E 211..216 CDD:409443 2/4 (50%)
Ig strand F 225..232 CDD:409443 0/6 (0%)
Ig strand G 235..245 CDD:409443 3/9 (33%)
IgI_3_FGFR 253..354 CDD:409363 18/101 (18%)
Ig strand A 253..256 CDD:409363 0/2 (0%)
Ig strand A' 260..264 CDD:409363 0/3 (0%)
Ig strand B 272..279 CDD:409363 2/6 (33%)
Ig strand C 283..290 CDD:409363 1/6 (17%)
Ig strand D 305..310 CDD:409363 0/4 (0%)
Ig strand E 321..326 CDD:409363 0/4 (0%)
Ig strand F 334..342 CDD:409363 3/8 (38%)
Ig strand G 345..353 CDD:409363 1/7 (14%)
Protein Kinases, catalytic domain 463..797 CDD:473864 114/299 (38%)

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