Protein Alignment Csk and FES

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001996.1
• Gene: FES / 2242
• HGNCID: 3657
• Length: 822
• Species: Homo sapiens
• Alignment Length: 876
• Identity: 230/876 - (26%)
• Similarity: 347/876 - (39%)
• Gaps: 239/876 - (27%)

  Fly   242 RERTSKNGQQTSRSLPPIASSEEWFDEEAQARKTSHE-----KSQ---------KPKPKPEENHK 292
            |||     ||..::.     ||:|...:.:..||..:     |||         :.|.|.:|..|
Human   107 RER-----QQLRKTY-----SEQWQQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASK 161

  Fly   293 EKEAISRK-----------ASGEGDLITVEIKQ------------GLLRK-----QTATTTTGQA 329
            :|:....|           |.....::.|...|            ||||.     :.......:.
Human   162 DKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEI 226

  Fly   330 MNSHATATQNGQTTVVGHHRGFSQPSVTVAAAAATGSTAGDPWFLQTTGH--QMPPTAPLRHNKR 392
            :..:...:...|..||..||..:      ||||.....|....||:..|.  .:||
Human   227 LQEYLEISSLVQDEVVAIHREMA------AAAARIQPEAEYQGFLRQYGSAPDVPP--------- 276

  Fly   393 PAPQPNAVLGAGSSGTAPGSAVGAVLLHQQQLSQSQPHIVPPSIPPHHHHHRENNVHPIQAGAAA 457
                                   .|...:..|.:.:|      :.|......|..|..:|
Human   277 -----------------------CVTFDESLLEEGEP------LEPGELQLNELTVESVQ----- 307

  Fly   458 ALHLSSHALNSHNLISSASNHSPKSPSQTQQQQQTTN-QQQQQQQQQASHSILSTFAPAPTVAAV 521
                       |.|.|.....:..:....::|:..|. ||:.:.:::.:|         |. ..|
Human   308 -----------HTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTH---------PR-ERV 351

  Fly   522 QPAGSQSV-----AGTAAAVAAVAQQQQQQHL--QLLANCPPGGAGLMSSSLNAAQMGMHGAERA 579
            |..|.:.|     .|...|:.:.|:.|.||.|  ..|.:..||.
Human   352 QLLGKRQVLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGE--------------------- 395

  Fly   580 LPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNA 644
             ||..|.|...:|.::    ::.|..:             |....:..:....|:|:....
Human   396 -PPPVLLLQDDRHSTS----SSEQERE-------------GGRTPTLEILKSHISGIFRPK---- 438

  Fly   645 SSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVR 709
                          .||.|    |.|.....:..|:...|:||:|.|.|...||.  ..|.||||
Human   439 --------------FSLPP----PLQLIPEVQKPLHEQLWYHGAIPRAEVAELLV--HSGDFLVR 483

  Fly   710 ESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQ------ 768
            ||.. ..:|.|.|.:.....|:.::.|:|...::.|. |.::..|:.|.      |.||
Human   484 ESQG-KQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEG-FPSIPLLIDHL------LSTQQPLTKK 540

  Fly   769 ----LIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILR--NEKVAVK 827
                |.:.:||              || ||:...:|.|.|.||:|.||:|..|.||  |..||||
Human   541 SGVVLHRAVPK--------------DK-WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVK 590

  Fly   828 MLKD---EGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQH 889
            ..::   .....|||.||.::....|.|:|:.||:....:.:|:|.|.:..|..:.:||:.|.:
Human   591 SCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGAR- 654

  Fly   890 ITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAREEC---YNLDVG- 950
            :..|..:....|.|:||||||:|..:||||||||.|::|..|.|:||||::|||.   |....|
Human   655 LRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGL 719

  Fly   951 -KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEG 1014
             ::|:||||||||..||:|::||:|||||||||.:|.|..|||.:......:.||.|.::..||.
Human   720 RQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPEL 784

  Fly  1015 CPPEIYEMMRQAWDLNPAKRPTFAELKVKLQ 1045
            ||..::.:|.|.|...|.:||:|:.:..:||
Human   785 CPDAVFRLMEQCWAYEPGQRPSFSTIYQELQ 815

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	31/106 (29%)
		PTKc_Csk_like	793..1047	CDD:270635	111/263 (42%)
FES	NP_001996.1	Important for interaction with membranes containing phosphoinositides	1..300		45/246 (18%)
		F-BAR_Fes	7..239	CDD:153369	26/141 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	394..421		8/65 (12%)
		SH2_Fps_family	453..537	CDD:198224	29/93 (31%)
		PTKc_Fes	564..815	CDD:270667	105/251 (42%)