DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and Txk

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_036020891.1	Gene:	Txk / 22165	MGIID:	102960	Length:	543	Species:	Mus musculus

Alignment Length:	383	Identity:	136/383 - (35%)
Similarity:	211/383 - (55%)	Gaps:	35/383 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   679 LNAMPWFHGSITRDEAEHLL-QPREDGLFLVRESTNFPGDYTLCVC------FQSKVEHYRVKYL 736
            |....|:|.:|||::.|.|| |..::|.|:||:|.:. |.||:.|.      .||.::||::|..
Mouse   174 LEIYEWYHKNITRNQTERLLRQEAKEGAFIVRDSRHL-GSYTISVFTRARRHTQSSIKHYQIKKN 237

  Fly   737 EN-KLTIDDEEYFENLGQLVAHYEADADGLCTQLI-------KCLPKLGKQEFCINSKDFVDKGW 793
            :: :..|.:...|.::.:|:.:::.:|.||.::|.       .|||.         :..|..:.|
Mouse   238 DSGQWYITERHLFPSVPELIQYHQYNAAGLISRLRYPIGLLGSCLPA---------TSGFSYEKW 293

  Fly   794 VIPEAELQLRESIGKGEFGDVMLGILR-NEKVAVKMLKDEGAV--QKFLAEASVMTTLEHDNLVK 855
            .|..:||...:.||.|:||.|.||..| :..||:|.: :||::  :.|:.||.||..|.|..||:
Mouse   294 EIDPSELAFVKEIGSGQFGVVHLGEWRAHIPVAIKAI-NEGSMSEEDFIEEAKVMMKLSHSRLVQ 357

  Fly   856 FIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLA 920
            ..|:....|.||:|||:|..|.|:||||.|..| :.|...:....|...||.|||....:|||||
Mouse   358 LYGVCIQQKPLYIVTEFMENGCLLDYLRERKGQ-LQKALLLSMCQDICEGMAYLERSCYIHRDLA 421

  Fly   921 ARNVLISEDCVAKVSDFGLAR----EECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLW 981
            |||.|:|..||.|:||||:||    :|..:....|.|:||..||.....::|:|||:||||:|:|
Mouse   422 ARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWSFGVLMW 486

  Fly   982 EIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAE 1039
            |:::.|::|:.......||:.:..|:::..|...|..||.:|...|. ...::|.|.|
Mouse   487 EVFTEGKMPFENKSNLQVVEAISQGFRLYRPHLAPMTIYRVMYSCWH-ETLQKPVFQE 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	33/111 (30%)
		PTKc_Csk_like	793..1047	CDD:270635	101/254 (40%)
		STYKc	800..1044	CDD:214568	98/247 (40%)
Txk	XP_036020891.1	SH3_TXK	114..168	CDD:212840
		SH2_Tec_Txk	172..277	CDD:198261	31/103 (30%)
		PKc_like	295..543	CDD:419665	99/250 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810