Protein Alignment Csk and PTK2B

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_004094.3
• Gene: PTK2B / 2185
• HGNCID: 9612
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 630
• Identity: 149/630 - (23%)
• Similarity: 248/630 - (39%)
• Gaps: 196/630 - (31%)

  Fly   469 HNLISSASNHS------------PKSPSQTQQQQQTTNQQQQQQQQQAS----------HSILST 511
            ||.:...||..            ||...:..:.:|.....||..||.||          .:.|:.
Human   192 HNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAG 256

  Fly   512 FAPAP--------------TV-AAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGGAGL 561
            ||...              || ..:.|.|.:.:....|....:|:.:|.:.::    |.|
Human   257 FANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLAEFKQIRSIR----CLP----- 312

  Fly   562 MSSSLNAAQMGMHGAERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMST 626
            :.......|:|:.||.:||..|:.:|:.:::.:::
Human   313 LEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADL------------------------------ 347

  Fly   627 SLHSFDINGVTAGSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITR 691
                  |:|.                                      |               |
Human   348 ------IDGY--------------------------------------C---------------R 353

  Fly   692 DEAEH----LLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFENLG 752
            .:.||    ::.||:||    .:..:.|....|.:       ..|..:|....:|:.:.|.|...
Human   354 LQGEHQGSLIIHPRKDG----EKRNSLPQIPMLNL-------EARRSHLSESCSIESDIYAEIPD 407

  Fly   753 QLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLG 817
            :                  .|.:.|..::.|..:|.|            |...:|:|.||:|..|
Human   408 E------------------TLRRPGGPQYGIAREDVV------------LNRILGEGFFGEVYEG 442

  Fly   818 ILRNEK-----VAVKMLKDEGAV---QKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMS 874
            :..|.|     ||||..|.:..:   :||::||.:|..|:|.::||.||:: ..:..:::.|...
Human   443 VYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGII-EEEPTWIIMELYP 506

  Fly   875 KGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLI-SEDCVAKVSDFG 938
            .|.|..|| .|.:..:.....::::......|.|||:...||||:|.||:|: |.:|| |:.|||
Human   507 YGELGHYL-ERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECV-KLGDFG 569

  Fly   939 LAR----EECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADV 999
            |:|    |:.|...|.:|||||.:||::...||:..||:|.|.:.:|||.|||:.|:..:...||
Human   570 LSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDV 634

  Fly  1000 VKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKL 1044
            :..:|.|.::..|:.|||.:|.:|.:.||.:|:.||.|.||...|
Human   635 IGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSL 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	15/100 (15%)
		PTKc_Csk_like	793..1047	CDD:270635	94/265 (35%)
PTK2B	NP_004094.3	FERM_N_2	39..137	CDD:436229
		B41	41..254	CDD:214604	13/61 (21%)
		FERM_C_FAK1	261..368	CDD:270011	24/204 (12%)
		PTKc_FAK	418..687	CDD:133187	97/277 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	701..725
		Interaction with TGFB1I1. /evidence=ECO:0000250	801..1009
		Focal adhesion targeting (FAT)	868..1009
		Focal_AT	872..1001	CDD:460992