DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csk and Tec

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001106931.1	Gene:	Tec / 21682	MGIID:	98662	Length:	630	Species:	Mus musculus

Alignment Length:	379	Identity:	136/379 - (35%)
Similarity:	213/379 - (56%)	Gaps:	22/379 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   679 LNAMPWFHGSITRDEAEHLLQPRE-DGLFLVRESTNFPGDYTLCVCFQ------SKVEHYRVKYL 736
            |:...|:..:..|.:||.||:..: :|.|:||:|:. ||.||:.:..:      |...||.:|..
Mouse   241 LDQYEWYCRNTNRSKAEQLLRTEDKEGGFMVRDSSQ-PGLYTVSLYTKFGGEGSSGFRHYHIKET 304

  Fly   737 ---ENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEA 798
               ..|..:.::..|.::.:::.:::.:|.||.|:|...:...||.  ...:..|....|.|..:
Mouse   305 ATSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSTKGKN--APTTAGFSYDKWEINPS 367

  Fly   799 ELQLRESIGKGEFGDVMLGILRNE-KVAVKMLKDEGAV--QKFLAEASVMTTLEHDNLVKFIGLV 860
            ||.....:|.|.||.|.||..|.: |||:|.:: |||:  :.|:.||.||..|.|..||:..|:.
Mouse   368 ELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR-EGAMCEEDFIEEAKVMMKLTHPKLVQLYGVC 431

  Fly   861 FTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVL 925
            ...|.:|:|||:|.:|.|:::||.| :.|.::...:....|...||||||....:||||||||.|
Mouse   432 TQQKPIYIVTEFMERGCLLNFLRQR-QGHFSRDMLLSMCQDVCEGMEYLERNSFIHRDLAARNCL 495

  Fly   926 ISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSF 986
            ::|..|.||||||:||   ::.|....| |.|:||..||.....|||:|||:||||:|:|||::.
Mouse   496 VNEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTE 560

  Fly   987 GRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            ||:|:.:....:||..|..|:::..|:.....:||:|.:.|...|..||:|.:|
Mouse   561 GRMPFEKNTNYEVVTMVTRGHRLHRPKLASKYLYEVMLRCWQERPEGRPSFEDL 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	26/106 (25%)
		PTKc_Csk_like	793..1047	CDD:270635	106/255 (42%)
		STYKc	800..1044	CDD:214568	103/248 (42%)
Tec	NP_001106931.1	PH_Btk	7..148	CDD:269944
		SH3_Tec	182..236	CDD:212838
		SH2_Tec_Itk	239..346	CDD:198259	27/105 (26%)
		PTKc_Tec_Rlk	364..623	CDD:270685	105/253 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810