DRSC/TRiP Functional Genomics Resources

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Protein Alignment Csk and Srms

DIOPT Version :9

Sequence 1:NP_001262476.1 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_035611.3 Gene:Srms / 20811 MGIID:101865 Length:507 Species:Mus musculus


Alignment Length:376 Identity:139/376 - (36%)
Similarity:217/376 - (57%) Gaps:20/376 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly   683 PWFHGSITRDEAEHLL--QPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYL-ENKLTIDD 744
            ||:...|:|.:|:.||  .....|.||:|.|.:..|.|:|.|..|:||.|||:... ...|.:.:
Mouse   134 PWYFSGISRAQAQQLLLSPANAPGAFLIRPSESSIGGYSLSVRAQAKVCHYRICMAPSGSLYLQE 198

  Fly   745 EEYFENLGQLVAHYEADADGLCTQLIK-CLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGK 808
            .:.|.:|..|:|:|:.:...:...|:: |:|::          ..|...|..|.:|..||..:|:
Mouse   199 GQLFPSLDALLAYYKTNWKLIQNPLLQPCIPQI----------PLVQDEWERPRSEFVLRRKLGE 253

  Fly   809 GEFGDVMLGI-LRNEKVAVKMLKD-EGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTE 871
            |.||:|..|: |.:..||||::|. :..:.....|...:.:|.|:.|::...:....:.:|:|||
Mouse   254 GFFGEVWEGLWLGSIPVAVKVIKSADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVTE 318

  Fly   872 YMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSD 936
            .|.||:|..||.|...:.::....:.||...|.||.|||.::||||||||||||:.:|...||:|
Mouse   319 LMGKGNLQVYLGSSEGKALSLPHLLGFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVAD 383

  Fly   937 FGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLA 997
            |||||   ::.|:...| |:|:|||||||.....||.|||:|||||||:|::::|:.||..:...
Mouse   384 FGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCPYEGMTNH 448

  Fly   998 DVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLLN 1048
            :.::.:..||::..|..||.|:|.:|.:.|..:|.:|||||.|:.||..:|
Mouse   449 ETLQQISRGYRLPRPAVCPAEVYVLMVECWKGSPEERPTFAILREKLNAIN 499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CskNP_001262476.1 SH2_csk_like 680..777 CDD:198190 31/97 (32%)
PTKc_Csk_like 793..1047 CDD:270635 106/259 (41%)
STYKc 800..1044 CDD:214568 101/249 (41%)
SrmsNP_035611.3 SH3 70..124 CDD:302595
SH2_Srm 134..212 CDD:198223 27/77 (35%)
PTKc_Srm_Brk 238..498 CDD:133248 106/259 (41%)
STYKc 246..495 CDD:214568 101/248 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D248674at33208
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.820

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