Protein Alignment Csk and Src

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_006499126.1
• Gene: Src / 20779
• MGIID: 98397
• Length: 552
• Species: Mus musculus
• Alignment Length: 543
• Identity: 187/543 - (34%)
• Similarity: 266/543 - (48%)
• Gaps: 67/543 - (12%)

  Fly   556 PGGAGLMSSSLNAAQMGMHGAERALP----PKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGV 616
            |..|.....||..:: .:|||..|.|    |...|.:....|.     :|...|.|::|....|.
Mouse     8 PKDASQRRRSLEPSE-NVHGAGGAFPASQTPSKPASADGHRGP-----SAAFVPPAAEPKLFGGF 66

  Fly   617 SGSG-----------SAGMSTSLHSFDING----------------VTAGSGVNASSAW------ 648
            :.|.           :.|::|.:..:|...                |.....|:.|..|
Mouse    67 NSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTRKVDVSQTWFTFRWL 131

  Fly   649 -SSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPRED--GLFLVRE 710
             ..|.....:..|...|...|....:..: .:.|..|:.|.|||.|:|.||...|:  |.|||||
Mouse   132 QREGDWWLAHSLSTGQTGYIPSNYVAPSD-SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRE 195

  Fly   711 STNFPGDYTLCVC-FQS----KVEHYRVKYLEN-KLTIDDEEYFENLGQLVAHYEADADGLCTQL 769
            |....|.|.|.|. |.:    .|:||:::.|:: ...|.....|.:|.||||:|...|||||.:|
Mouse   196 SETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL 260

  Fly   770 IKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILR-NEKVAVKMLKDEG 833
            ....|....|     ::......|.||...|:|...:|:|.||:|.:|... ..:||:|.|| .|
Mouse   261 TTVCPTSKPQ-----TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK-PG 319

  Fly   834 AV--QKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQI 896
            .:  :.||.||.||..|.|:.||:...:| :.:.:|:|||||:||||:|:|:....:::.....:
Mouse   320 TMSPEAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLV 383

  Fly   897 IFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWT 957
            ..:...||||.|:|....|||||.|.|:|:.|:.|.||:||||||   :..|....| |.|||||
Mouse   384 DMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 448

  Fly   958 APEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEM 1022
            ||||...|||:.|||:|||||||.|:.:.||||||.:...:|:..||.||:|..|..||..::::
Mouse   449 APEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDL 513

  Fly  1023 MRQAWDLNPAKRPTFAELKVKLQ 1045
            |.|.|...|.:||||..|:..|:
Mouse   514 MCQCWRKEPEERPTFEYLQAFLE 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	42/104 (40%)
		PTKc_Csk_like	793..1047	CDD:270635	115/260 (44%)
Src	XP_006499126.1	SH3_Src	87..159	CDD:212941	10/71 (14%)
		SH2_Src_Src	163..263	CDD:198228	41/99 (41%)
		PTKc_Src	276..552	CDD:270656	115/263 (44%)