DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and Ptk6

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_033210.1	Gene:	Ptk6 / 20459	MGIID:	99683	Length:	451	Species:	Mus musculus

Alignment Length:	372	Identity:	140/372 - (37%)
Similarity:	205/372 - (55%)	Gaps:	17/372 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   683 PWFHGSITRDEAEHLLQPRED--GLFLVRESTNFPGDYTLCVCFQSKVEHYRV-KYLENKLTIDD 744
            |||.|.|:|.||.|.||..::  |.||:|.|.....||.|.|.....|.|||: |..|.:|.:::
Mouse    77 PWFFGCISRSEAMHRLQAEDNSKGAFLIRVSQKPGADYVLSVRDAQAVRHYRIWKNNEGRLHLNE 141

  Fly   745 EEYFENLGQLVAHYEADADGLCTQL-IKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGK 808
            ...|.||.:||.:::..:.....|| :.|...  |.|...:..|     |..|..|..|.:.:|.
Mouse   142 AVSFSNLSELVDYHKTQSLSHGLQLSMPCWKH--KTEPLPHWDD-----WERPREEFTLCKKLGA 199

  Fly   809 GEFGDVMLGILRNE-KVAVKMLKDEGAVQK--FLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVT 870
            |.||:|...:.:.: .||||::..:..:.:  |.||...|..|.|.:::....:......:|::|
Mouse   200 GYFGEVFEALWKGQVHVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDPVYIIT 264

  Fly   871 EYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVS 935
            |.|.||:|:..||....:.:...:.:.||...|.||.|||::..:||||||||||::|:.:.||.
Mouse   265 ELMPKGNLLQLLRDSDEKALPILELVDFASQVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVG 329

  Fly   936 DFGLAR---EECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLA 997
            ||||||   |:.|......:|.||||||||..|.:|.|||:||||:||.||:|.|::|||.:...
Mouse   330 DFGLARLVKEDIYLSHEHNVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEIFSRGQMPYPGMSNH 394

  Fly   998 DVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKL 1044
            :....|:.||:|..|..|||.|:::|...|..:|.:||.|.:|..||
Mouse   395 ETFLRVDAGYRMPCPLECPPNIHKLMLSCWSRDPKQRPCFKDLCEKL 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	35/97 (36%)
		PTKc_Csk_like	793..1047	CDD:270635	102/258 (40%)
		STYKc	800..1044	CDD:214568	97/249 (39%)
Ptk6	NP_033210.1	SH3	12..69	CDD:302595
		SH2_PTK6_Brk	75..174	CDD:198221	35/98 (36%)
		Linker	171..190		5/25 (20%)
		PKc_like	184..444	CDD:304357	102/258 (40%)
		STYKc	192..441	CDD:214568	97/248 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820