DRSC/TRiP Functional Genomics Resources

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Protein Alignment Csk and Ripk1

DIOPT Version :10

Sequence 1:NP_731611.2 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_033094.3 Gene:Ripk1 / 19766 MGIID:108212 Length:656 Species:Mus musculus


Alignment Length:297 Identity:83/297 - (27%)
Similarity:134/297 - (45%) Gaps:53/297 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   774 PKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVML------GILRNEKVAVKMLKDE 832
            |.:......:.|.|.::|            ..:..|.||.|.|      |.:..:||.....:.|
Mouse     3 PDMSLDNIKMASSDLLEK------------TDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAE 55

  Fly   833 GAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQII 897
             ..:..|.|..:|..|.|..:||.:|::....:..||.|||.||:|:..|:::....::.|.:||
Mouse    56 -YNEVLLEEGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRII 119

  Fly   898 FAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAREECYNLDVGKL---------- 952
              .:...||.||..|.|:|:||...|:|:..|...|::|.|:|..:.::    ||          
Mouse   120 --VEAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWS----KLTKEKDNKQKE 178

  Fly   953 -----------PIKWTAPEALK--NGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAD-VVKHV 1003
                       .:.:.|||.|.  |.:.:.|||::||||:||.|:: .:.||..:...: .|..:
Mouse   179 VSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFA-KKEPYENVICTEQFVICI 242

  Fly  1004 EVGYK---MEAPEGCPPEIYEMMRQAWDLNPAKRPTF 1037
            :.|.:   .|..|.||.||..:|.:.|...|..||||
Mouse   243 KSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTF 279

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CskNP_731611.2 SH2_csk_like 680..777 CDD:198190 1/2 (50%)
PTKc_Csk_like 793..1047 CDD:270635 79/278 (28%)
Ripk1NP_033094.3 Protein Kinases, catalytic domain 23..291 CDD:473864 79/265 (30%)
Interaction with SQSTM1. /evidence=ECO:0000250|UniProtKB:Q13546 291..567
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 327..373
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..423
RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:18442983, ECO:0000269|PubMed:27819681, ECO:0000269|PubMed:27819682 520..536
Death_RIP1 568..653 CDD:260048
Blue background indicates that the domain is not in the aligned region.

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