DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Csk and Ret

DIOPT Version :10

Sequence 1:NP_731611.2 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_033076.2 Gene:Ret / 19713 MGIID:97902 Length:1115 Species:Mus musculus


Alignment Length:606 Identity:157/606 - (25%)
Similarity:242/606 - (39%) Gaps:163/606 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   561 LMSSSLNAAQMG-------------MHGAERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAA 612
            |..||:|...:|             ::..|....|:...|..:      ::.|..|..:.:|.:.
Mouse   444 LQPSSINCTALGVVTSPEDTSGTLFVNDTEALRRPECTKLQYT------VVATDRQTRRQTQASL 502

  Fly   613 VVGVSGSGSAGMSTSLHSFDIN----------GVTAGSGVNASSAWSSGSTTAM--NHASLSPTA 665
            ||.|.|:..........|..:|          |:.:.:|   ...|..|....:  |.::.||:.
Mouse   503 VVTVEGTSITEEVGCPKSCAVNKRRPECEECGGLGSPTG---RCEWRQGDGKGITRNFSTCSPST 564

  Fly   666 LAPQQGRSRCEV----KLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQS 726
            .....|  .|:.    ..|..|  ...:..|    ::...|.|     |.......|.:|.||..
Mouse   565 RTCPDG--HCDAVESRDANICP--QDCLRAD----IVGGHERG-----ERQGIKAGYGICNCFPD 616

  Fly   727 KVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIK---------------CL--- 773
                      |.|...:.|   ::.|.|       .|.||..:|.               |:   
Mouse   617 ----------EKKCFCEPE---DSQGPL-------CDALCRTIITAALFSLIISILLSIFCVCHH 661

  Fly   774 ------PKLGKQE--FCINSKDF-----------------------------VDKGWVIPEAELQ 801
                  |.:...|  ||..::.|                             .|..|..|...|.
Mouse   662 HKHGHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSTENQVPVDSFKIPEDPKWEFPRKNLV 726

  Fly   802 LRESIGKGEFGDV-------MLGILRNEKVAVKMLKD---EGAVQKFLAEASVMTTLEHDNLVKF 856
            |.:::|:||||.|       :.|......|||||||:   :..::..|:|.:::..:.|.:::|.
Mouse   727 LGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIKL 791

  Fly   857 IGLVFTSKHLYLVTEYMSKGSLVDYLR-----------------SRGRQH-----ITKKDQIIFA 899
            .|.......|.|:.||...|||..:||                 |....|     :|..|.|.||
Mouse   792 YGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSGGGSRNSSSLDHPDERVLTMGDLISFA 856

  Fly   900 YDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR----EECY-NLDVGKLPIKWTAP 959
            :..:.||:||...|:|||||||||:|::|....|:|||||:|    |:.| ....|::|:||.|.
Mouse   857 WQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAI 921

  Fly   960 EALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMR 1024
            |:|.:..::.:||:||||:|||||.:.|..|||.||...:...::.|::||.|:.|..|:|.:|.
Mouse   922 ESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 986

  Fly  1025 QAWDLNPAKRPTFAELKVKLQ 1045
            |.|...|.|||.||::...|:
Mouse   987 QCWKQEPDKRPVFADISKDLE 1007

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CskNP_731611.2 SH2_csk_like 680..777 CDD:198190 21/120 (18%)
PTKc_Csk_like 793..1047 CDD:270635 105/290 (36%)
RetNP_033076.2 RET_CLD1 29..154 CDD:465485
Cadherin-like region 1 (CLD1). /evidence=ECO:0000250|UniProtKB:P07949 29..153
Cadherin 173..262 CDD:394985
Cadherin-like region 3 (CLD3). /evidence=ECO:0000250|UniProtKB:P07949 266..380
RET_CLD3 266..380 CDD:465516
Cadherin-like region 4 (CLD4). /evidence=ECO:0000250|UniProtKB:P07949 407..508 14/69 (20%)
RET_CLD4 409..508 CDD:465517 14/69 (20%)
PTKc_RET 724..1013 CDD:173631 103/284 (36%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.