Protein Alignment Csk and frk-1

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001369901.1
• Gene: frk-1 / 191635
• WormBaseID: WBGene00001487
• Length: 390
• Species: Caenorhabditis elegans
• Alignment Length: 377
• Identity: 115/377 - (30%)
• Similarity: 197/377 - (52%)
• Gaps: 21/377 - (5%)

  Fly   679 LNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTID 743
            :.:..::||.:.|.:||..|  :.:|.||||::...||...|.:..:...|..| .::.|.....
 Worm    18 IRSAEYYHGMVPRQDAEGFL--KREGDFLVRKTEQMPGKVVLAMSVRVTDELCR-HFMLNMDPTS 79

  Fly   744 DEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGK 808
            ::.|||:     .|.|:....|....:.....:.........:......|:|....:...:.:|:
 Worm    80 NKFYFEH-----THQESTISELINWHMTTKTPISAASGAKIRRPMERSPWLINHDSIVANKKLGE 139

  Fly   809 GEFGDVMLGIL---RNEKVAVKMLKDEG---AVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLY 867
            |.||||.:..|   ..::||||.::.|.   |..:|:.||.:|...:|.::||.||:......|.
 Worm   140 GAFGDVFIAELDQGGKQEVAVKTMRAEATREARLRFMKEARLMRKYQHKHVVKLIGVAIHEHPLM 204

  Fly   868 LVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVA 932
            :|.||...|||:.:|:   :..::..:::.|..:.|.|:.|||..|.:|||:||||.|:|.....
 Worm   205 IVMEYCPNGSLLSHLK---KNKVSLIEKLRFTTEAADGIAYLERSKCIHRDIAARNCLLSAKNEL 266

  Fly   933 KVSDFGLA--REECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRI- 994
            |:||||::  ::|..:..:.|:||||.|||.::...:::|:|:|:||:|:|||||.|..|||.:
 Worm   267 KISDFGMSDNKDEIKDETLEKVPIKWLAPETMQEKVYTHKTDIWTFGVLVWEIYSDGAEPYPGLT 331

  Fly   995 PLADVVKHVEVGYKMEAPEGCPPEIYEMMR-QAWDLNPAKRPTFAELKVKLQ 1045
            .:....|.|...|:|:.|:|..|.:.:::. ..|..||.||.|...:..||:
 Worm   332 KIQTRAKIVVNDYRMKMPDGTHPTVADVVTGTCWQKNPEKRSTMDSIHKKLR 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	23/96 (24%)
		PTKc_Csk_like	793..1047	CDD:270635	92/263 (35%)
frk-1	NP_001369901.1	SH2_Fps_family	16..107	CDD:198224	23/96 (24%)
		TyrKc	131..382	CDD:197581	88/253 (35%)