Protein Alignment Csk and C25A8.5

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_501081.1
• Gene: C25A8.5 / 182879
• WormBaseID: WBGene00016085
• Length: 416
• Species: Caenorhabditis elegans
• Alignment Length: 416
• Identity: 130/416 - (31%)
• Similarity: 205/416 - (49%)
• Gaps: 80/416 - (19%)

  Fly   683 PWFHGSITRDEAEHLLQPREDGLFLVRES---TNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDD 744
            ||:||.:.|::.:.:|  |::|.||||.:   ...|..|.|......::|...||:...:|...:
 Worm    10 PWYHGLLPREDIKAML--RKNGDFLVRSTEPKAGEPRQYVLSAMQSEELEDAGVKHYVMRLNPSN 72

  Fly   745 EEY-----FENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDK-----------GW 793
            :.:     ||.:..||.:|                        :|||:.:.|           .|
 Worm    73 QIFLEAKGFETIASLVNYY------------------------MNSKEPIKKMTVLKTPILKQPW 113

  Fly   794 VIPEAELQLRESIGKGEFGDVMLG--ILRN---EKVAVKMLKDEG----AVQKFLAEASVMTTLE 849
            .|..::::|.:.:|:|.||:|..|  .|:|   |..|:|..|.|.    .:::.:.||.:|..|:
 Worm   114 EIEHSQVELTKKLGEGAFGEVWKGKLTLKNGTVENCAIKTAKLESLNKEQIKEIMREARLMRNLD 178

  Fly   850 HDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKV 914
            |.|:|||.|:..:.:.||::.|....|:|..||:........||.::|  |..|.|:.|:..||:
 Worm   179 HPNVVKFYGVGASQEPLYVIMELADCGALDSYLQKNPNLLPGKKMEMI--YQAACGIAYMHEKKL 241

  Fly   915 VHRDLAARNVLISEDCVAKVSDFGLARE-ECYNLDV-GKLPIKWTAPEALKNGRFSNKSDMWSFG 977
            :|||:||||.|..|..| |::||||:|| ..|.:|: .|:||:|.|||.||.|.:|.|||:::||
 Worm   242 LHRDIAARNCLYGEGQV-KIADFGLSREGNSYVMDLTKKVPIRWLAPETLKAGIYSPKSDVFAFG 305

  Fly   978 ILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYE------MMRQAWDLNPAKR-- 1034
            |:.|||...|:.|||.:.:::||.:|..|::|.    ..|...:      :.:..|..||..|
 Worm   306 IMAWEITENGKEPYPDMRVSEVVGYVRSGHRMR----FDPVFVDFRFGEYVTKHCWAENPDDRVN 366

  Fly  1035 ---------PTFAELKVKLQLLNNAT 1051
                     .||....|.|.|.|..|
 Worm   367 MSDVLRYLQTTFGMKPVILSLRNRTT 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	24/101 (24%)
		PTKc_Csk_like	793..1047	CDD:270635	99/281 (35%)
C25A8.5	NP_501081.1	SH2_Fps_family	4..98	CDD:198224	27/113 (24%)
		PTKc	124..375	CDD:270623	92/257 (36%)