Protein Alignment Csk and abl-1

DIOPT Version :9

• Sequence 1: NP_001262476.1
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_509778.2
• Gene: abl-1 / 181261
• WormBaseID: WBGene00000018
• Length: 1224
• Species: Caenorhabditis elegans
• Alignment Length: 561
• Identity: 184/561 - (32%)
• Similarity: 284/561 - (50%)
• Gaps: 53/561 - (9%)

  Fly   523 PAGSQSVAGTAAAVAA-VAQQQQQQHLQLLANCPPGGAGLMSSSLNAAQMGMHGAERALPPK--S 584
            |...|.||...:.::: :|::.::....|:....|       .:.::.||.....:...||.  |
 Worm    22 PVFDQPVASPKSEISSKLAEEIERSKSPLILEVSP-------RTPDSVQMFRPTFDTFRPPNSDS 79

  Fly   585 LALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGS--------- 640
            ....|||...:::..::............|..|.|.||.:..:|  :|.:||....
 Worm    80 STFRGSQSREDLVACSSMNSVNNVHDMNTVSSSSSSSAPLFVAL--YDFHGVGEEQLSLRKGDQV 142

  Fly   641 ---GVNASSAWSSGS--TTAMNHAS----------LSPTALAPQQGRSRCEVKLNAMPWFHGSIT 690
               |.|.::.|....  :|..|.||          :....:||..       .|:...|:||.|:
 Worm   143 RILGYNKNNEWCEARLYSTRKNDASNQRRLGEIGWVPSNFIAPYN-------SLDKYTWYHGKIS 200

  Fly   691 RDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLEN--KLTIDDEEYFENLGQ 753
            |.::|.:|.....|.||||||....|.||:.|....:|.|||:. ::|  |:.|..|..|..||:
 Worm   201 RSDSEAILGSGITGSFLVRESETSIGQYTISVRHDGRVFHYRIN-VDNTEKMFITQEVKFRTLGE 264

  Fly   754 LVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGI 818
            ||.|:...||||...|:....|..|.....:........|.:..:|:.:...:|.|::|||..|.
 Worm   265 LVHHHSVHADGLICLLMYPASKKDKGRGLFSLSPNAPDEWELDRSEIIMHNKLGGGQYGDVYEGY 329

  Fly   819 LRNE--KVAVKMLKDEG-AVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVD 880
            .:..  .:|||.||::. .:.:|||||::|..|.|.|||:.:|:.......|::||:|..|:|::
 Worm   330 WKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLE 394

  Fly   881 YLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---E 942
            |||...:..:.....:..|...||||.||||:..:||||||||.|:||..:.|::||||||   |
 Worm   395 YLRRTDKSLLPPIILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKE 459

  Fly   943 ECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVG 1006
            :.|....| |.||||||||.|....||:|||:|:||:|||||.::|..|||.:.|::|...:|.|
 Worm   460 DTYTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVYGLLENG 524

  Fly  1007 YKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLL 1047
            ::|:.|:||||.:|.:|.|.|:.:|:.||.|.::...|:.|
 Worm   525 FRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLENL 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	38/98 (39%)
		PTKc_Csk_like	793..1047	CDD:270635	110/260 (42%)
		STYKc	800..1044	CDD:214568	107/250 (43%)
abl-1	NP_509778.2	SH3_Abl	119..185	CDD:212784	11/67 (16%)
		SH2_ABL	190..283	CDD:198189	37/93 (40%)
		PTKc_Abl	304..566	CDD:270645	111/262 (42%)
		Pkinase_Tyr	311..562	CDD:285015	107/250 (43%)
		FABD	1091..1224	CDD:197885

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920