Protein Alignment Csk and hir-1

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_504458.1
• Gene: hir-1 / 178936
• WormBaseID: WBGene00016059
• Length: 903
• Species: Caenorhabditis elegans
• Alignment Length: 963
• Identity: 222/963 - (23%)
• Similarity: 348/963 - (36%)
• Gaps: 302/963 - (31%)

  Fly   183 PARSTPTTTTTSATSAKHESSPPIDARLLNFLRCAHRKFQASKAKTELQQTKDRFLGNSRERTSK 247
            |.::.|..|..:....:..|..|:...::.::     .::...:||   .|.|.|:...::....
 Worm    80 PEKTLPAPTNLTLKGVRGLSWSPVPGAVMYYI-----GYRTLNSKT---FTSDDFVITEKQTVDL 136

  Fly   248 NGQQTSRSLPP--------IASSEEWFDEEAQARKTSHEKSQKPKPKPEENHKEKEAISRKASGE 304
            :   |..::.|        .|.||:....|::..|.|       .|||..|.|.
 Worm   137 S---TLTNIDPCSELEVAVAAFSEDGIGNESKELKIS-------SPKPTANPKL----------- 180

  Fly   305 GDLITVEIKQGLLRKQTATTTTGQAMNSHATATQNGQTTVVGHHRGFSQPSVTVAAAAATGSTAG 369
             ||:.:                 |.:|          ||:|.   .|.|.:.||.......:
 Worm   181 -DLLEL-----------------QYLN----------TTLVS---DFYQANATVHVEFRYKT--- 211

  Fly   370 DPWFLQTTGHQMPPTAPLRHNKRPAPQPNAVLGAGSSGTAPGSAVGAVLLHQQQLSQSQPHIVPP 434
            |||||   |.......||.|                       .:..|   ...|||..|
 Worm   212 DPWFL---GPDDLDVQPLFH-----------------------LISCV---DPDLSQGIP----- 242

  Fly   435 SIPPHHHHHRENNVHPIQAGAAAALHLSSHALNSHNLISSASNHSPKSPSQTQQQQQTTNQQQQQ 499
              .|....|.:|:......|:........:.....:::|...|...:.||......||.
 Worm   243 --VPDFDVHVKNSTISTSIGSDMMDRKCRYVYYLQSVMSKKCNTMTEMPSPPSSALQTI------ 299

  Fly   500 QQQQASHSILSTFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGGAGLMSS 564
               |....|:.. ||...|.:.||    .:.|....||.....:.:::|    |.|.....:..:
 Worm   300 ---QVECDIVKN-APCVKVPSYQP----PLCGMVENVAFSVLSRDRENL----NDPASNLTVNVT 352

  Fly   565 SLNAAQ---------MGMHGAERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSG 620
            .:...:         :|:.|            :.|::      ||       .:....:||:.:.
 Worm   353 FIPVTRNNEMPTLYYIGIFG------------TASEY------HT-------KEEETFLGVNITH 392

  Fly   621 SAGMSTSLHSFDINGVTAGSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVK--LN-AM 682
            ..|..:|...||.:|......:|.|....          .:.|..|   .|.:.|.||  .| .:
 Worm   393 VIGKESSCTGFDSSGNCLAENLNRSIVLQ----------GIHPKTL---YGLTICAVKDIRNLTL 444

  Fly   683 PWFHGSITRDEAEHLLQPREDGLFLVRESTNFP---------GDYTLCVC--------FQSKVEH 730
            |    .:|.|...  .:.:.|.:.||..::|.|         |...:.:.        |:.|.|:
 Worm   445 P----DVTLDSKS--FRAKADRIMLVAHTSNNPVGMIIGIVIGSLVVILVAIVVIWFYFRKKSEN 503

  Fly   731 YRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVD----- 790
            .:.|:.                                    :.::||.    |...::|
 Worm   504 MKFKFQ------------------------------------MEQVGKN----NMNRYIDFPIMA 528

  Fly   791 -KG--WVIPEAELQLR--ESIGKGEFGDVMLGIL---------------------RNEKVAVKML 829
             |.  |.|....|.:.  :.:|.|.||.|.||.|                     .|.:||||||
 Worm   529 AKNDIWEIERRNLIIHNDKKLGSGAFGAVYLGKLIGKSLAHKDANSPLGINLMRAENCQVAVKML 593

  Fly   830 ---KDEGAVQKFLAEASVMTTL-EHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGR--- 887
               .||.:..:||.|.::|.|| .|:.||..:..|..|:.|.||.||...|.|:.:||.|.:
 Worm   594 PEYADEMSKHEFLREIALMKTLGYHERLVNMLACVTESEPLCLVVEYCDNGDLLKFLRERCKYMM 658

  Fly   888 --------QH-------------ITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCV 931
                    .|             :|.|..:.||...:.|:|||..|..||||:||||||:.|...
 Worm   659 KLDDLGINYHDPPENENYDTNMIVTLKQLLQFAVQISYGLEYLSQKGFVHRDVAARNVLVHEGTA 723

  Fly   932 AKVSDFGLAR-----EECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPY 991
            .|:.||||.|     :..|....||||:||.:|||:::..||.|||:|||||||:|:.:.|..||
 Worm   724 CKIGDFGLCRYIYADQSQYKSKGGKLPLKWMSPEAIRHYEFSIKSDIWSFGILLFEVITLGGSPY 788

  Fly   992 PRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKL 1044
            |.:|..||:..:|.|.::|.|:.||...|::|.|.|:.:|..|..|::::::|
 Worm   789 PGMPPEDVLPFLEGGGRIEKPDNCPENFYDVMMQCWNADPDDRIEFSDVRMQL 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	14/114 (12%)
		PTKc_Csk_like	793..1047	CDD:270635	112/308 (36%)
hir-1	NP_504458.1	fn3	85..164	CDD:394996	14/89 (16%)
		RGP	227..>281	CDD:385243	11/86 (13%)
		PTKc	547..842	CDD:270623	109/295 (37%)