Protein Alignment Csk and ced-2

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_500105.1
• Gene: ced-2 / 176968
• WormBaseID: WBGene00000416
• Length: 279
• Species: Caenorhabditis elegans
• Alignment Length: 324
• Identity: 73/324 - (22%)
• Similarity: 126/324 - (38%)
• Gaps: 111/324 - (34%)

  Fly   684 WFHGSITRDEAEHLL-QPRED-GLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEE 746
            :|.| ::|:||..|| :|:.. |.||:|:|:. ||:|:|.|                      .|
 Worm    15 YFPG-MSREEAHKLLGEPQVSIGTFLMRDSSR-PGEYSLTV----------------------RE 55

  Fly   747 YFENLGQLVAHY-----EADADGLCTQLIKCLPKLGKQEFCINSKDFVD--------KGWVIPEA 798
            ..|  |..|.||     |...||.....:|           |.::.|.|        |..|:.||
 Worm    56 ADE--GNAVCHYLIERGEPKEDGTAAAGVK-----------IANQSFPDIPALLNHFKMRVLTEA 107

  Fly   799 ELQLRESIGKGEFGDVMLGILR--NEKVAVKMLKDEGAVQKFLAEASVMTTLEHDNLVKFIGLVF 861
            .|.   :..|....:|::|..:  .|: ...:..::|...:.|::.: ....|..|.:...|||
 Worm   108 SLL---AAYKKPIIEVVVGTFKFTGER-ETDLPFEQGERLEILSKTN-QDWWEARNALGTTGLV- 166

  Fly   862 TSKHLYLVTEY----MSKGSLVDYLRSRG------------------RQHITKKDQIIF-----A 899
            .:.::.:..|:    .|||:....:.|.|                  :..:..|.::.|     |
 Worm   167 PANYVQIQMEFHNDRTSKGASQSSIGSSGGGAERFSSASTSSDNIELQPRLPAKAKVTFDRVPNA 231

  Fly   900 YDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAREECYNLD--VGKLP---IKWTA 958
            ||...    |..||       .:.||:::    |:|: |:.:.|   ||  :|.:|   :::||
 Worm   232 YDPTQ----LRVKK-------GQTVLVTQ----KMSN-GMYKAE---LDGQIGSVPHTYLRFTA 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	28/99 (28%)
		PTKc_Csk_like	793..1047	CDD:270635	41/200 (21%)
ced-2	NP_500105.1	SH2	6..116	CDD:472789	37/140 (26%)
		SH3_Nck_3	120..173	CDD:212701	10/55 (18%)
		SH3	218..274	CDD:473055	18/74 (24%)