Protein Alignment Csk and R05H5.4

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_496201.1
• Gene: R05H5.4 / 174581
• WormBaseID: WBGene00011039
• Length: 414
• Species: Caenorhabditis elegans
• Alignment Length: 383
• Identity: 120/383 - (31%)
• Similarity: 192/383 - (50%)
• Gaps: 31/383 - (8%)

  Fly   682 MPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPG-DYTLCVCFQSKVEHYRVKYLENKLTIDDE 745
            :|:|||::...:|:.||....|.:..:::..:... ...|.|..:..:..|.:|.......|..:
 Worm    14 LPYFHGALMNIDADQLLVNEGDFMVTMKKQLDINKLQLFLAVRLKKGIRRYEIKRTSKTAKIGGK 78

  Fly   746 EYFENLGQLVAHYEAD---ADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIG 807
            . .:|:.:|:...:||   ..|....|.:.:|| ||  |.:..||.:            .::.||
 Worm    79 T-SQNIVKLINMLKADPIEIRGEKVVLKRAIPK-GK--FQLMHKDVI------------FQKKIG 127

  Fly   808 KGEFGDVMLG--ILRNEKVAVKMLKDEGAVQKFLA----EASVMTTLEHDNLVKFIGLVFTSKHL 866
            .|.:|.|..|  :..:|.:|||.|..|||.:..||    ||.||...:|.|:|||.|.:......
 Worm   128 AGAYGTVYRGKLVKTDEVIAVKKLDPEGADEDGLAEMMKEARVMQLYDHPNIVKFHGFILDDLPY 192

  Fly   867 YLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCV 931
            .||.||.:.|::.|.||.:| :.|....::.:.|..|.||:||..|..:|||:|:||.||.:. |
 Worm   193 LLVLEYCNGGAVEDRLRDKG-EKIKVPTRVKYTYMAACGMDYLHKKNCIHRDIASRNCLIHKG-V 255

  Fly   932 AKVSDFGLAR-EECYNLDVGK-LPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFG-RVPYPR 993
            .|::|||:.| :..|.:|:.| ..|:|.|||...||.....:|:::|||::||.:... :.||..
 Worm   256 VKMADFGMCRAQSVYKVDLKKPCNIRWLAPEVWDNGETRFNTDVYAFGIMMWEFFETPFKSPYVE 320

  Fly   994 IPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLLNNAT 1051
            :..|.|.:....||::..|...|..:.|:|.:.|.::..||||..|||.||:.....|
 Worm   321 MKAAQVKRKTRAGYRLPPPPSMPSRMVEIMSECWQVDAEKRPTAEELKEKLEEFKKKT 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	21/98 (21%)
		PTKc_Csk_like	793..1047	CDD:270635	93/262 (35%)
R05H5.4	NP_496201.1	SH2_Fps_family	9..97	CDD:198224	17/83 (20%)
		TyrKc	120..363	CDD:197581	86/256 (34%)