Protein Alignment Csk and src-2

DIOPT Version :9

• Sequence 1: NP_001262476.1
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_493502.1
• Gene: src-2 / 173296
• WormBaseID: WBGene00005078
• Length: 507
• Species: Caenorhabditis elegans
• Alignment Length: 512
• Identity: 181/512 - (35%)
• Similarity: 256/512 - (50%)
• Gaps: 45/512 - (8%)

  Fly   555 PPGGAGLM--SSSLNAAQMGMHGAERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPAAVVGV- 616
            |||....:  ||:|....:..|....::.|.:.:.||         :|..:....||.|..|.:
 Worm    11 PPGATSPVHTSSTLGRESLPSHPRIPSIGPIAASSSG---------NTIDKNQNISQSANFVALF 66

  Fly   617 SGSGSAGMSTSLHSFDINGVTAGSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNA 681
            ..........|....||..:...         :.|......|.:...|...|....:| |..:.:
 Worm    67 QYDARTDDDLSFKKDDILEILND---------TQGDWWFARHKATGRTGYIPSNYVAR-EKSIES 121

  Fly   682 MPWFHGSITRDEAE----HLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLEN-KLT 741
            .||:.|.:.|.:||    |.|  .|.|.||||:|.:...|.:|.|.....|:|||::.|:: ...
 Worm   122 QPWYFGKMRRIDAEKCLLHTL--NEHGAFLVRDSESRQHDLSLSVRENDSVKHYRIRQLDHGGYF 184

  Fly   742 IDDEEYFENLGQLVAHYEADADGLCTQL-IKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRES 805
            |.....|..|..|:|||:.:|||||..| ..|    .|.|....:....|..|.:....::|...
 Worm   185 IARRRPFATLHDLIAHYQREADGLCVNLGAPC----AKSEAPQTTTFTYDDQWEVDRRSVRLIRQ 245

  Fly   806 IGKGEFGDVMLGILR-NEKVAVKMLKDEGA-VQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYL 868
            ||.|:||:|..|... |..||||.||...| ...|||||.:|..|.|..|:....:....:.:.:
 Worm   246 IGAGQFGEVWEGRWNVNVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKLLSLYAVCTRDEPILI 310

  Fly   869 VTEYMSKGSLVDYLRSRGRQHITKKDQII-FAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVA 932
            |||.|.: :|:.:|:.||||  .:..|:: .:...|:||.|||....:||||||||:||:.....
 Worm   311 VTELMQE-NLLTFLQRRGRQ--CQMPQLVEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSV 372

  Fly   933 KVSDFGLAR----EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYP 992
            |::||||||    |..|....| :.|||||||||....||:.|||:|||||||.||.:|||:|||
 Worm   373 KIADFGLARILMKENEYEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGRLPYP 437

  Fly   993 RIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLLNN 1049
            .:..|:|::.|:.||:|..|.|||..:|::|:|.|..:|.|||||..|:.||:.|.|
 Worm   438 GMTNAEVLQQVDAGYRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQWKLEDLFN 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	37/102 (36%)
		PTKc_Csk_like	793..1047	CDD:270635	115/261 (44%)
		STYKc	800..1044	CDD:214568	112/251 (45%)
src-2	NP_493502.1	SH3_Src_like	61..112	CDD:212779	8/59 (14%)
		SH2_Src_Src42	120..215	CDD:198233	36/96 (38%)
		PTKc_Frk_like	231..496	CDD:270653	117/267 (44%)
		Pkinase_Tyr	240..489	CDD:285015	112/251 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820