Protein Alignment Csk and F26E4.5

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_492594.2
• Gene: F26E4.5 / 172828
• WormBaseID: WBGene00009160
• Length: 474
• Species: Caenorhabditis elegans
• Alignment Length: 495
• Identity: 143/495 - (28%)
• Similarity: 224/495 - (45%)
• Gaps: 89/495 - (17%)

  Fly   584 SLALSGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNASSAW 648
            |.:....:|.....:.||.:.|.....|.....|...|..:|.|:..            :|.:..
 Worm     3 SASRGNRRHKDRSEVETAVRGPDLLLKATDETSSDGASTSLSKSVEE------------SAPNKD 55

  Fly   649 SSGSTTAMNHASLSPTALAPQQGRSRCE-VKLNAMPWFHGSITRDEAEHLLQPREDGLFLVR--E 710
            .|.|:...:|..|. ..|......|.|. ..|:..|::||.::|:|:|.|:  |..|.||:|  |
 Worm    56 KSNSSLVKSHHVLK-IKLKKITNWSGCSGALLDDEPFYHGYMSREESEKLV--RSQGEFLLRKTE 117

  Fly   711 STNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPK 775
            .|.......|.|.:...|.|..|:...|.|....|..|||:..||.::......:....||....
 Worm   118 LTKRGEVVVLSVFWDEGVHHLVVEKANNGLYYLKEFCFENISDLVRYHHQTRASVYKSGIKLFSW 182

  Fly   776 LGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGIL------RNEKVAVKMLK---- 830
            :.::|            |.:...::.|.:.:|.||||:|..|:|      .:.:||||.:|
 Worm   183 VVREE------------WQLYHEQINLGKKLGNGEFGEVFQGVLSVGIFTNDVEVAVKTMKGSKV 235

  Fly   831 --DEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKK 893
              ||...  ||.||::|..|.|..:|:..|:....:.:.:|.|..|.|.|        :..|.||
 Worm   236 TADERIT--FLREANLMLKLNHKYVVRLYGVATQQEPIMIVMELCSGGCL--------KSRIEKK 290

  Fly   894 DQII-------FAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLA------REECY 945
            |:.:       :....|.||.|||.|:|:||||||||||:.:....|:|||||:      :|:
 Worm   291 DEQLSDVLKRKYCKQIAKGMRYLEKKQVIHRDLAARNVLLDKSDNCKISDFGLSLFGKLHKEQ-- 353

  Fly   946 NLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADV---------VK 1001
              .:.|:||:|.|||.|..|.:|:|||:||||::::|::| |..||     |||         |.
 Worm   354 --KLMKVPIRWLAPETLLKGIYSSKSDVWSFGVVMFEVFS-GEYPY-----ADVKVLKELRRKVA 410

  Fly  1002 HVEVGYKMEAPEGCPPEIYEMMRQAWDLNPA-KRPTFAEL 1040
            |..:  :::.|...|.:..::|...::  |. .|.||.::
 Worm   411 HENL--RLKPPSDMPTDDAKVMEMCFE--PVDNRATFVQV 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	29/98 (30%)
		PTKc_Csk_like	793..1047	CDD:270635	94/283 (33%)
F26E4.5	NP_492594.2	SH2_Fps_family	86..172	CDD:198224	28/87 (32%)
		TyrKc	195..449	CDD:197581	93/276 (34%)