Protein Alignment Csk and kin-14

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_492004.1
• Gene: kin-14 / 172440
• WormBaseID: WBGene00002198
• Length: 418
• Species: Caenorhabditis elegans
• Alignment Length: 444
• Identity: 134/444 - (30%)
• Similarity: 213/444 - (47%)
• Gaps: 79/444 - (17%)

  Fly   642 VNASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLF 706
            :|.::..||.||::|...|         .|:.:..      .||||.:.|.:|:.||.  :.|.|
 Worm     3 LNGNATDSSSSTSSMTENS---------DGQKQNN------EWFHGVLQRQDADELLV--KPGSF 50

  Fly   707 LVRES-TNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYF-------ENLGQLVA-HYEADA 762
            |:|.| .:......|.|....|:.:..|       ..|..|.|       :::.|||. |.....
 Worm    51 LLRASEVHGKMSMILSVRHDGKLHNIAV-------NSDTGENFWFEGHREKSIDQLVQWHMTTST 108

  Fly   763 DGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGIL----RNEK 823
            ....|..:|....:||.:            |:|....:...:.:|:|.||:|.|...    |..:
 Worm   109 PITKTSGVKLKYPIGKAD------------WIISHENVIFIKKLGEGAFGEVSLAECEIGGRKVE 161

  Fly   824 VAVK-----MLKDEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKH------------LYLVTE 871
            .|||     |.:|..|.  |:.||.:|....|.::|:.||.:.. ||            |.:|.|
 Worm   162 TAVKTMRCQMTRDTRAA--FMKEARLMRKYSHPHIVRIIGKIIV-KHLPKVGLAVDAHPLMIVME 223

  Fly   872 YMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSD 936
            ....|||:.:|| :.:...|..:::.|..::|.|:.|||.|:.:|||:||||.|:|.....|:||
 Worm   224 MCPHGSLLSFLR-KNKGKTTLSERLRFCIESADGLAYLEKKQCLHRDIAARNCLLSITDQIKISD 287

  Fly   937 FGLA---REECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAD 998
            |||:   |.|.::..:.|:|:||.|||.:::..:|.|||:|:||:|:||||:.|..|||  .:.:
 Worm   288 FGLSDDKRTEMHDDTLDKVPVKWLAPEVMQDKLYSLKSDVWAFGVLMWEIYADGADPYP--GMTN 350

  Fly   999 VVKHVEV---GYKMEAPEGCPPEIYEM-MRQAWDLNPAKRPTFAELKVKLQLLN 1048
            :|...::   .|:|..||..||.|.|: ::|.|...|:.|.|...:..||:.|:
 Worm   351 LVTRAKIFCDDYRMTFPETTPPTISEIALKQCWAKLPSDRATMKTVHHKLKDLS 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	26/105 (25%)
		PTKc_Csk_like	793..1047	CDD:270635	97/281 (35%)
kin-14	NP_492004.1	SH2_Fps_family	26..110	CDD:198224	24/98 (24%)
		PTKc	138..401	CDD:270623	94/268 (35%)