Protein Alignment Csk and src-1

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001364829.1
• Gene: src-1 / 171722
• WormBaseID: WBGene00005077
• Length: 537
• Species: Caenorhabditis elegans
• Alignment Length: 525
• Identity: 180/525 - (34%)
• Similarity: 255/525 - (48%)
• Gaps: 93/525 - (17%)

  Fly   589 GSQHGSNMLLHTA--PQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNASSAWSSG 651
            ||..|.:..:..:  |:..|..|...|..|:..|:.|..:.|     ||.:.|...|.......|
 Worm    13 GSDMGVSERIDVSRYPRRFQTPQQQTVFHVNNGGNEGTISQL-----NGTSDGMMGNGRGGGGGG 72

  Fly   652 STTAMNHASLSPTALAPQQGR------------------SRC----------------------- 675
            .  |....:|  .||.|...|                  |.|
 Worm    73 G--AQERETL--VALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAK 133

  Fly   676 EVKLNAMPWFHGSITRDEAEHLL----QPREDGLFLVRESTNFPGDYTLCVCFQ------SKVEH 730
            :..:.:..|:.|.|.|:.||.|:    .|:  |.||:||......::.|.:...      ..|:|
 Worm   134 QQTIESEEWYAGKIPRNRAERLVLSSHLPK--GTFLIREREADTREFALTIRDTDDQRNGGTVKH 196

  Fly   731 YRVKYLENKLTIDDEEY-------FENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDF 788
            |::|.|::     |:.|       |.:|.:||.:|....||||.||....|:|......: |.|
 Worm   197 YKIKRLDH-----DQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDL-SHD- 254

  Fly   789 VDKGWVIPEAELQLRESIGKGEFGDVMLGILRN-EKVAVKMLKDEGAV--QKFLAEASVMTTLEH 850
            ..:.|.||..:|.|:..:|.|.||:|..|..|. .:||:|.:| .|.:  :.||.||.:|...:|
 Worm   255 TQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMK-PGTMSPEAFLQEAQIMKQCDH 318

  Fly   851 DNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVV 915
            .||||...:....:..|::||||..|||:.|||:.| ..:..:..:..|...|:||.|||.:|:|
 Worm   319 PNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDG-STLGIQALVDMAAQIANGMMYLEERKLV 382

  Fly   916 HRDLAARNVLISEDC----VAKVSDFGLAR----EECYNLDVG-KLPIKWTAPEALKNGRFSNKS 971
            ||||||||||:.:..    |.||:||||||    |:.|....| |.|||||||||...|.|:.||
 Worm   383 HRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKWTAPEAATCGNFTVKS 447

  Fly   972 DMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIY-EMMRQAWDLNPAKRP 1035
            |:||:||||:||.:.|:||||.:...:||:.||:||:|..|.|||.:|| |::.:.||..|.:||
 Worm   448 DVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRP 512

  Fly  1036 TFAEL 1040
            ||..|
 Worm   513 TFDTL 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	33/113 (29%)
		PTKc_Csk_like	793..1047	CDD:270635	120/261 (46%)
src-1	NP_001364829.1	SH3_Src_like	79..130	CDD:212779	7/52 (13%)
		SH2_Src_family	138..240	CDD:199827	32/108 (30%)
		PTKc_Src_like	270..522	CDD:270630	115/250 (46%)