Protein Alignment Csk and Lck

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001155904.1
• Gene: Lck / 16818
• MGIID: 96756
• Length: 520
• Species: Mus musculus
• Alignment Length: 492
• Identity: 170/492 - (34%)
• Similarity: 256/492 - (52%)
• Gaps: 58/492 - (11%)

  Fly   588 SGSQHGSNMLLHTAPQPPQAS-QPAAVVGVSGSGSAGMSTSLHSFDIN-----GVTAGSGV---- 642
            :||:....::.:....||.:. |...|:            :|||::.:     |...|..:
Mouse    51 NGSEVRDPLVTYEGSLPPASPLQDNLVI------------ALHSYEPSHDGDLGFEKGEQLRILE 103

  Fly   643 NASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAM---PWFHGSITRDEAE-HLLQP-RE 702
            .:...|.:.|.|......:....:|          |.|::   |||..:::|.:|| .||.| ..
Mouse   104 QSGEWWKAQSLTTGQEGFIPFNFVA----------KANSLEPEPWFFKNLSRKDAERQLLAPGNT 158

  Fly   703 DGLFLVRESTNFPGDYTLCV-CFQSK----VEHYRVKYLEN-KLTIDDEEYFENLGQLVAHYEAD 761
            .|.||:|||.:..|.::|.| .|...    |:||:::.|:| ...|.....|..|..||.||...
Mouse   159 HGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHDLVRHYTNA 223

  Fly   762 ADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILR-NEKVA 825
            :|||||:|.:.......|      |.:.:..|.:|...|:|.|.:|.|:||:|.:|... :.|||
Mouse   224 SDGLCTKLSRPCQTQKPQ------KPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVA 282

  Fly   826 VKMLKDEGAV--QKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQ 888
            ||.|| :|::  ..|||||::|..|:|..||:...:| |.:.:|::||||..|||||:|::....
Mouse   283 VKSLK-QGSMSPDAFLAEANLMKQLQHPRLVRLYAVV-TQEPIYIITEYMENGSLVDFLKTPSGI 345

  Fly   889 HITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG 950
            .:.....:..|...|.||.::|.:..:||||.|.|:|:|:....|::||||||   :..|....|
Mouse   346 KLNVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 410

  Fly   951 -KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEG 1014
             |.|||||||||:..|.|:.|||:|||||||.||.:.||:|||.:...:|::::|.||:|..|:.
Mouse   411 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDN 475

  Fly  1015 CPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLLNNAT 1051
            ||.|:|.:|...|...|..||||..|:..|.....||
Mouse   476 CPEELYHLMMLCWKERPEDRPTFDYLRSVLDDFFTAT 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	38/107 (36%)
		PTKc_Csk_like	793..1047	CDD:270635	112/260 (43%)
Lck	NP_001155904.1	SH3_Lck	76..129	CDD:212938	10/74 (14%)
		SH2_Src_Lck	134..234	CDD:198225	37/99 (37%)
		PTKc_Lck_Blk	248..511	CDD:270652	112/264 (42%)