DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Csk and Jak3

DIOPT Version :9

Sequence 1:NP_001262476.1 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_001177759.1 Gene:Jak3 / 16453 MGIID:99928 Length:1100 Species:Mus musculus


Alignment Length:700 Identity:170/700 - (24%)
Similarity:266/700 - (38%) Gaps:184/700 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   499 QQQQQASHSILSTFAP----APTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLA---NCPP 556
            :|....:.|::....|    ...:||...:|.: |.|.|..:.:....:.::...|:.   .|.|
Mouse   428 RQDPSGAFSLVGLSQPHRSLRELLAACWNSGLR-VDGAALNLTSCCAPRPKEKSNLIVVRRGCTP 491

  Fly   557 GGA-GLMSSSLNAAQMGMHGAERALPPKSL---------------------ALSGSQHGSNML-- 597
            ..| |...|.....|:..|    .:|..||                     .:.|..|.|.:|  
Mouse   492 APAPGCSPSCCALTQLSFH----TIPTDSLEWHENLGHGSFTKIFRGRRREVVDGETHDSEVLLK 552

  Fly   598 -------------LHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGS--------G 641
                         |..|....|.|.|..|: :.|...||.|..:..|    |..|:        |
Mouse   553 VMDSRHRNCMESFLEAASLMSQVSYPHLVL-LHGVCMAGDSIMVQEF----VYLGAIDMYLRKRG 612

  Fly   642 VNASSAWSSGSTTAMNHA--------------------------------------SLSPTAL-- 666
            ...|::|....|..:.:|                                      .:|||.|  
Mouse   613 HLVSASWKLQVTKQLAYALNYLEDKGLPHGNVSARKVLLAREGGDGNPPFIKLSDPGVSPTVLSL 677

  Fly   667 ----------APQQGRSRCEVKLNAMPWFHGSIT-------------RDEAEHLLQPREDGLFLV 708
                      ||:..:....:.|.|..|..|:.|             .:.|:.|....:.|....
Mouse   678 EMLTDRIPWVAPECLQEAQTLGLEADKWGFGATTWEVFSGGPAHITSLEPAKKLKFYEDQGQLPA 742

  Fly   709 RESTNFPGDYTLCVCFQ-SKVEHYR--VKYLENKLTIDDEEYFENLGQLVAHYEADADGLC--TQ 768
            .:.|...|..|.|:.:. .:...:|  ::.|...:|.|    :|.|........:..|.||  .|
Mouse   743 LKWTELAGLITQCMAYDPGRRPSFRAILRDLNGLITSD----YELLSDPTPGIPSPRDELCGGAQ 803

  Fly   769 LIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDV------MLGILRNEKVAVK 827
            |..|....                 :..|..|:....:|||.||.|      .||......||||
Mouse   804 LYACQDPA-----------------IFEERHLKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVK 851

  Fly   828 MLKDEGAVQK--FLAEASVMTTLEHDNLVKFIGLVF--TSKHLYLVTEYMSKGSLVDYL-RSRGR 887
            .|:..|..|:  |..|..::..|..|.:||:.|:.:  ..:.|.||.||:..|.|.|:| |.|.|
Mouse   852 QLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR 916

  Fly   888 QHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR-----EECYNL 947
            .|..:  .::||:....|||||.|::.|||||||||:|:..:...|::|||||:     ::.|.:
Mouse   917 LHTDR--LLLFAWQICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPLGKDYYVV 979

  Fly   948 -DVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSF---GRVPYPRI-----------PLA 997
             :.|:.||.|.|||:|.:..||.:||:||||::|:|::::   ...|....           ||.
Mouse   980 REPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLSMMGPEREGPPLC 1044

  Fly   998 DVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLL 1047
            .:::.:..|.::..|..||.|:.|:|:..|..:|..||.|..|..:|..|
Mouse  1045 RLLELLAEGRRLPPPPTCPTEVQELMQLCWAPSPHDRPAFGTLSPQLDAL 1094

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CskNP_001262476.1 SH2_csk_like 680..777 CDD:198190 23/114 (20%)
PTKc_Csk_like 793..1047 CDD:270635 97/284 (34%)
STYKc 800..1044 CDD:214568 95/274 (35%)
Jak3NP_001177759.1 Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250 1..223
B41 41..246 CDD:214604
FERM_C_JAK3 250..359 CDD:275413
SH2 359..455 CDD:301589 5/26 (19%)
PKc_like 517..774 CDD:304357 42/261 (16%)
Pkinase_Tyr 517..773 CDD:285015 42/260 (16%)
PKc_like 813..1095 CDD:304357 97/283 (34%)
Pkinase_Tyr 818..1091 CDD:285015 95/274 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.