Protein Alignment Csk and Jak2

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_032439.2
• Gene: Jak2 / 16452
• MGIID: 96629
• Length: 1132
• Species: Mus musculus
• Alignment Length: 287
• Identity: 93/287 - (32%)
• Similarity: 163/287 - (56%)
• Gaps: 32/287 - (11%)

  Fly   797 EAELQLRESIGKGEFGDV------MLGILRNEKVAVKMLK--DEGAVQKFLAEASVMTTLEHDNL 853
            |..|:..:.:|||.||.|      .|.....|.||||.|:  .|..::.|..|..::.:|:|||:
Mouse   846 ERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNI 910

  Fly   854 VKFIGLVFTS--KHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVH 916
            ||:.|:.:::  ::|.|:.||:..|||.|||: :.::.|..|..:.:......|||||..|:.:|
Mouse   911 VKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQ-KHKERIDHKKLLQYTSQICKGMEYLGTKRYIH 974

  Fly   917 RDLAARNVLISEDCVAKVSDFGLAR-----EECYNL-DVGKLPIKWTAPEALKNGRFSNKSDMWS 975
            ||||.||:|:..:...|:.||||.:     :|.|.: :.|:.||.|.|||:|...:||..||:||
Mouse   975 RDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWS 1039

  Fly   976 FGILLWEIYSF---------------GRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQ 1025
            ||::|:|::::               |.....::.:..:::.::...::..|||||.|||.:|.:
Mouse  1040 FGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEGCPDEIYVIMTE 1104

  Fly  1026 AWDLNPAKRPTFAELKVKLQLLNNATA 1052
            .|:.|.::||:|.:|.:::..:.::.|
Mouse  1105 CWNNNVSQRPSFRDLSLRVDQIRDSIA 1131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190
		PTKc_Csk_like	793..1047	CDD:270635	92/280 (33%)
Jak2	NP_032439.2	Interaction with cytokine/interferon/growth hormone receptors	1..239
		FERM_F1	39..134	CDD:465733
		FERM_F2	143..261	CDD:436450
		FERM_C_JAK2	266..386	CDD:270141
		SH2_Jak2	386..482	CDD:198242
		PTK_Jak2_rpt1	545..806	CDD:270663
		PTKc_Jak2_rpt2	844..1127	CDD:271107	92/281 (33%)