DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Csk and Jak1

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_666257.2	Gene:	Jak1 / 16451	MGIID:	96628	Length:	1153	Species:	Mus musculus

Alignment Length:	427	Identity:	112/427 - (26%)
Similarity:	189/427 - (44%)	Gaps:	88/427 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   672 RSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYL 736
            |..|   :..:||.......|         ...|.:..:..:| |.....:|:..::.      |
Mouse   748 RQEC---IERIPWIAPECVED---------SKNLSVAADKWSF-GTTLWEICYNGEIP------L 793

  Fly   737 ENKLTIDDEEYFEN-----------LGQLVA---HYEADADGLCTQLIKCLPKLGKQEFCINSKD 787
            ::|..|:.|.::|:           |..|:.   :|:.:.......:::.:.||.:|     :.|
Mouse   794 KDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQ-----NPD 853

  Fly   788 FVDKGWVIPEAE--------LQLRESIGKGEFGDVML------GILRNEKVAVKMLKDEGA---V 835
            .|.:.....|.:        |:....:|:|.||.|.|      |....|:||||.||.|..   :
Mouse   854 IVSEKQPTTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHI 918

  Fly   836 QKFLAEASVMTTLEHDNLVKFIGLVFT--SKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIF 898
            .....|..::..|.|:|:||:.|:...  ...:.|:.|::..|||.:|| .:.:..|..|.|:.:
Mouse   919 ADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYL-PKNKNKINLKQQLKY 982

  Fly   899 AYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR-----EECYNL-DVGKLPIKWT 957
            |.....||:||.:::.|||||||||||:..:...|:.||||.:     :|.|.: |....|:.|.
Mouse   983 AIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWY 1047

  Fly   958 APEALKNGRFSNKSDMWSFGILLWEIYSF-------------------GRVPYPRIPLADVVKHV 1003
            |||.|...:|...||:||||:.|.|:.::                   |::...|:     |..:
Mouse  1048 APECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRL-----VNTL 1107

  Fly  1004 EVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            :.|.::..|..||.|:|::||:.|:..|:.|.||..|
Mouse  1108 KEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNL 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	16/110 (15%)
		PTKc_Csk_like	793..1047	CDD:270635	90/292 (31%)
		STYKc	800..1044	CDD:214568	89/277 (32%)
Jak1	NP_666257.2	FERM_F1	<52..129	CDD:408179
		FERM_F2	147..277	CDD:408177
		FERM_C_JAK1	282..426	CDD:275412
		SH2_Jak1	426..526	CDD:198241
		PTK_Jak1_rpt1	582..845	CDD:270662	17/115 (15%)
		PTKc_Jak1_rpt2	869..1152	CDD:173644	89/282 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810