DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and Itk

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001268894.1	Gene:	Itk / 16428	MGIID:	96621	Length:	625	Species:	Mus musculus

Alignment Length:	414	Identity:	141/414 - (34%)
Similarity:	221/414 - (53%)	Gaps:	46/414 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   658 HASLSPTALAPQQGRSRCEVKLNAMPWFHGSITRDEAEH-LLQPREDGLFLVRESTNFPGDYTLC 721
            |...:|::...::..:    .|....|::.||:||:||. ||...::|.|:||:|.. ||.||:.
Mouse   223 HEGYAPSSYLVEKSPN----NLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRT-PGTYTVS 282

  Fly   722 V----------CFQSKVEHYRVKYLEN---KLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCL 773
            |          |    ::||.:|...:   :..:.::..|:::..|:.:::.:..||.|:|
Mouse   283 VFTKAIISENPC----IKHYHIKETNDSPKRYYVAEKYVFDSIPLLIQYHQYNGGGLVTRL---- 339

  Fly   774 PKLGKQEFCI-NSKDFVDKG-----WVIPEAELQLRESIGKGEFGDVMLGI-LRNEKVAVKMLKD 831
                :...|. ..|..|..|     |||..:||...:.||.|:||.|.||. |..:|||:|.::
Mouse   340 ----RYPVCSWRQKAPVTAGLRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQ- 399

  Fly   832 EGAV--QKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKD 894
            |||:  :.|:.||.||..|.|..||:..|:......:.||.|:|..|.|.|||||: |.....:.
Mouse   400 EGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQ-RGLFAAET 463

  Fly   895 QIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIK 955
            .:....|...||.|||...|:||||||||.|:.|:.|.||||||:.|   ::.|....| |.|:|
Mouse   464 LLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVK 528

  Fly   956 WTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIY 1020
            |.:||.....|:|:|||:||||:|:||::|.|::||.....::||:.:..|:::..|......:|
Mouse   529 WASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASCHVY 593

  Fly  1021 EMMRQAWDLNPAKRPTFAELKVKL 1044
            ::|...|...|..||.|::|..:|
Mouse   594 QIMNHCWKEKPEDRPPFSQLLSQL 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	29/110 (26%)
		PTKc_Csk_like	793..1047	CDD:270635	105/259 (41%)
		STYKc	800..1044	CDD:214568	100/250 (40%)
Itk	NP_001268894.1	PH	5..117	CDD:278594
		PH_Btk	7..154	CDD:269944
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..174
		SH3_ITK	180..235	CDD:212841	2/11 (18%)
		SH2_Tec_Itk	238..345	CDD:198259	30/123 (24%)
		PTKc_Itk	363..618	CDD:133243	103/257 (40%)
		Pkinase_Tyr	368..617	CDD:285015	100/250 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810