Protein Alignment Csk and Hck

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_034537.2
• Gene: Hck / 15162
• MGIID: 96052
• Length: 524
• Species: Mus musculus
• Alignment Length: 491
• Identity: 171/491 - (34%)
• Similarity: 266/491 - (54%)
• Gaps: 57/491 - (11%)

  Fly   588 SGSQHGSNMLLHTAPQPP---QASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGV---NASS 646
            |.|:.|.|   ::...||   :.|:...||.:..      ..::|..|::.......|   .|..
Mouse    56 SSSKLGPN---NSNSMPPGFVEGSEDTIVVALYD------YEAIHREDLSFQKGDQMVVLEEAGE 111

  Fly   647 AWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAM---PWFHGSITRDEAE-HLLQPRED-GLF 706
            .|.:.|........:....:|          ::|::   .||...|:|.:|| |||.|... |.|
Mouse   112 WWKARSLATKKEGYIPSNYVA----------RVNSLETEEWFFKGISRKDAERHLLAPGNMLGSF 166

  Fly   707 LVRESTNFPGDYTLCV-CFQSK----VEHYRVKYLEN-KLTIDDEEYFENLGQLVAHYEADADGL 765
            ::|:|....|.|:|.| .|..:    |:||:::.|:: ...|.....|.:|.:||.||:...|||
Mouse   167 MIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISPRSTFSSLQELVLHYKKGKDGL 231

  Fly   766 CTQL-IKCL-PKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGIL-RNEKVAVK 827
            |.:| :.|: ||        ..|.:....|.||...||:.:.:|.|:||:|.:... ::.|||||
Mouse   232 CQKLSVPCVSPK--------PQKPWEKDAWEIPRESLQMEKKLGAGQFGEVWMATYNKHTKVAVK 288

  Fly   828 MLKDEG-AVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSR--GRQH 889
            .:|... :|:.|||||::|.:|:||.||| :..|.:.:.:::|||:|:||||:|:|:|.  .:|.
Mouse   289 TMKPGSMSVEAFLAEANLMKSLQHDKLVK-LHAVVSQEPIFIVTEFMAKGSLLDFLKSEEGSKQP 352

  Fly   890 ITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG- 950
            :.|  .|.|:...:.||.::|.:..:||||.|.|:|:|...|.|::||||||   :..|....|
Mouse   353 LPK--LIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGA 415

  Fly   951 KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGC 1015
            |.|||||||||:..|.|:.|||:|||||||.||.::||:|||.:...:|::.:|.||:|..|:.|
Mouse   416 KFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPDNC 480

  Fly  1016 PPEIYEMMRQAWDLNPAKRPTFAELKVKLQLLNNAT 1051
            |.|:|.:|.:.|...|.:||||..::..|.....||
Mouse   481 PEELYNIMIRCWKNRPEERPTFEYIQSVLDDFYTAT 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	39/109 (36%)
		PTKc_Csk_like	793..1047	CDD:270635	113/261 (43%)
Hck	NP_034537.2	SH3	80..135	CDD:473055	9/70 (13%)
		SH2_Src_HCK	138..241	CDD:198226	36/102 (35%)
		Protein Kinases, catalytic domain	252..522	CDD:473864	115/268 (43%)