Protein Alignment Csk and Grb2

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_032189.1
• Gene: Grb2 / 14784
• MGIID: 95805
• Length: 217
• Species: Mus musculus
• Alignment Length: 148
• Identity: 44/148 - (29%)
• Similarity: 78/148 - (52%)
• Gaps: 23/148 - (15%)

  Fly   677 VKLNAMPWFHGSITRDEAEHLL-QPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRV------K 734
            :::...|||.|.|.|.:||.:| :.|.||.||:|||.:.|||::|.|.|.:.|:|::|      |
Mouse    53 IEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGK 117

  Fly   735 YLENKLTIDDEEYFENLGQLVAHYEADADGLCTQL-IKCLPKLGKQEFCINSK-DFVDKGWVIPE 797
            |.   |.:   ..|.:|.:||.::.:.:.....|: ::.:.::.:|...:.:. ||..:    .:
Mouse   118 YF---LWV---VKFNSLNELVDYHRSTSVSRNQQIFLRDIEQMPQQPTYVQALFDFDPQ----ED 172

  Fly   798 AELQLRESIGKGEFGDVM 815
            .||..|    :|:|..||
Mouse   173 GELGFR----RGDFIHVM 186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	34/104 (33%)
		PTKc_Csk_like	793..1047	CDD:270635	7/23 (30%)
Grb2	NP_032189.1	SH3_GRB2_N	1..56	CDD:212879	0/2 (0%)
		SH2_Grb2_like	56..150	CDD:199828	34/99 (34%)
		SH3_GRB2_C	160..212	CDD:212882	9/35 (26%)