DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and CSK

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001120662.1	Gene:	CSK / 1445	HGNCID:	2444	Length:	450	Species:	Homo sapiens

Alignment Length:	370	Identity:	231/370 - (62%)
Similarity:	278/370 - (75%)	Gaps:	6/370 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   678 KLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTI 742
            ||:.||||||.|||::||.||.|.|.||||||||||:||||||||....||||||:.|..:||:|
Human    76 KLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSI 140

  Fly   743 DDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKD-FVDKGWVIPEAELQLRESI 806
            |:|.|||||.|||.||.:|||||||:|||  ||:  .|..:.::| |...||.:...||:|.::|
Human   141 DEEVYFENLMQLVEHYTSDADGLCTRLIK--PKV--MEGTVAAQDEFYRSGWALNMKELKLLQTI 201

  Fly   807 GKGEFGDVMLGILRNEKVAVKMLKDEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSK-HLYLVT 870
            |||||||||||..|..|||||.:|::...|.|||||||||.|.|.|||:.:|::...| .||:||
Human   202 GKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVT 266

  Fly   871 EYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVS 935
            |||:|||||||||||||..:.....:.|:.|....|||||....|||||||||||:|||.|||||
Human   267 EYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVS 331

  Fly   936 DFGLAREECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVV 1000
            ||||.:|.....|.||||:||||||||:..:||.|||:|||||||||||||||||||||||.|||
Human   332 DFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV 396

  Fly  1001 KHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQ 1045
            ..||.||||:||:||||.:||:|:..|.|:.|.||:|.:|:.:|:
Human   397 PRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLE 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	67/96 (70%)
		PTKc_Csk_like	793..1047	CDD:270635	158/254 (62%)
		STYKc	800..1044	CDD:214568	155/244 (64%)
CSK	NP_001120662.1	Interaction with PTPN22. /evidence=ECO:0000250\|UniProtKB:P41241	9..70
		SH3_CSK	11..67	CDD:212703
		SH2_csk_like	78..175	CDD:198190	67/100 (67%)
		PTKc_Csk	188..443	CDD:133213	158/254 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	316	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55818
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm42131
orthoMCL	1	0.900	-	-		OOG6_107422
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3150
SonicParanoid	1	1.000	-	-		X2621
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.840