Protein Alignment Csk and Fyn

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_030100741.1
• Gene: Fyn / 14360
• MGIID: 95602
• Length: 576
• Species: Mus musculus
• Alignment Length: 532
• Identity: 181/532 - (34%)
• Similarity: 260/532 - (48%)
• Gaps: 98/532 - (18%)

  Fly   588 SGSQHGSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNASSA----- 647
            ||.::|      |.|.|    |.....||:   |.....:.|:....|:|...|||:||.
Mouse    65 SGYRYG------TDPTP----QHYPSFGVT---SIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLR 116

  Fly   648 ------------------------------------------WSSGSTTAMNHASLSPTALAPQQ 670
                                                      |.:.|.|......:....:||..
Mouse   117 TRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVD 181

  Fly   671 GRSRCEVKLNAMPWFHGSITRDEAEHLL----QPREDGLFLVRESTNFPGDYTLCV-----CFQS 726
                   .:.|..|:.|.:.|.:||..|    .||  |.||:|||....|.|:|.:     ....
Mouse   182 -------SIQAEEWYFGKLGRKDAERQLLSFGNPR--GTFLIRESETTKGAYSLSIRDWDDMKGD 237

  Fly   727 KVEHYRVKYLEN-KLTIDDEEYFENLGQLVAHYEADADGLCTQLI----KCLPKLGKQEFCINSK 786
            .|:||:::.|:| ...|.....||.|.|||.||...|.|||.:|:    |.:|:|  .:..:.:|
Mouse   238 HVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRL--TDLSVKTK 300

  Fly   787 DFVDKGWVIPEAELQLRESIGKGEFGDVMLGILR-NEKVAVKMLKDEGAV--QKFLAEASVMTTL 848
            |.    |.||...|||.:.:|.|:||:|.:|... |.|||:|.|| .|.:  :.||.||.:|..|
Mouse   301 DV----WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLK-PGTMSPESFLEEAQIMKKL 360

  Fly   849 EHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKK 913
            :||.||:...:| :.:.:|:||||||||||:|:|:....:.:...:.:..|...|:||.|:|...
Mouse   361 KHDKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMN 424

  Fly   914 VVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMW 974
            .:||||.:.|:|:....:.|::||||||   :..|....| |.|||||||||...|||:.|||:|
Mouse   425 YIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 489

  Fly   975 SFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAE 1039
            ||||||.|:.:.||||||.:...:|::.||.||:|..|:.||..::|:|...|..:|.:||||..
Mouse   490 SFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEY 554

  Fly  1040 LKVKLQLLNNAT 1051
            |:..|:....||
Mouse   555 LQGFLEDYFTAT 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	39/110 (35%)
		PTKc_Csk_like	793..1047	CDD:270635	114/260 (44%)
Fyn	XP_030100741.1	SH3_Fyn_Yrk	124..179	CDD:212939	3/54 (6%)
		SH2_Src_Fyn_isoform_a_like	184..284	CDD:198281	37/101 (37%)
		PTKc_Fyn	300..573	CDD:270655	118/273 (43%)