DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and Frk

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001153016.1	Gene:	Frk / 14302	MGIID:	103265	Length:	512	Species:	Mus musculus

Alignment Length:	477	Identity:	172/477 - (36%)
Similarity:	250/477 - (52%)	Gaps:	52/477 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   602 PQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVT-------AGSGVNASSAWSSGSTTAMNHA 659
            |:.|::.:|....|         ...:..||....|       ||..:........|...| .|.
Mouse    38 PEAPRSQEPERSHG---------QYFVALFDYQARTAEDLSFRAGDKLQVLDTSHEGWWLA-RHL 92

  Fly   660 SLSPTALAPQ-QG----------RSRCEVKLNAMPWFHGSITRDEAEH--LLQPREDGLFLVRES 711
            ....|.|..| ||          ||     |.|.|||.|:|.|.:||.  |....:.|.||:|||
Mouse    93 EKKGTGLGQQLQGYIPSNYVAEDRS-----LQAEPWFFGAIKRADAEKQLLYSENQTGAFLIRES 152

  Fly   712 TNFPGDYTLCVCFQSKVEHYRVKYL-ENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIK-CLP 774
            .:..||::|.|..:..|:|||::.| |....:...:.|..|.:.|.:|...:||||.:|.| ||.
Mouse   153 ESQKGDFSLSVLDEGVVKHYRIRRLDEGGFFLTRRKVFSTLNEFVNYYTTTSDGLCVKLEKPCLK 217

  Fly   775 KLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRN-EKVAVKMLKDEGAV--Q 836
            ......|.::.|. .|: |.|....:||.:.:|.|:||:|..|:..| ..||||.|| .|::  .
Mouse   218 IQVPTPFDLSYKT-ADQ-WEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLK-PGSMDPN 279

  Fly   837 KFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYD 901
            .||.||.:|.:|.|..|::...:......:|::||.|..|||.:||::.|...|....|:..|..
Mouse   280 DFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIHLIQQVDMAAQ 344

  Fly   902 TASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR------EECYNL--DVGKLPIKWTA 958
            .||||.|||::..:||||||||||:.|..:.||:||||||      |:.|..  :: |||:||||
Mouse   345 VASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEI-KLPVKWTA 408

  Fly   959 PEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMM 1023
            |||::..:||.|||:|||||||:||.::|::||..:..|.|::.:...|::..|..||.:.|.:|
Mouse   409 PEAIRTNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLSQNYRLPQPSNCPQQFYSIM 473

  Fly  1024 RQAWDLNPAKRPTFAELKVKLQ 1045
            .:.|::.|.:||||..|..||:
Mouse   474 LECWNVEPKQRPTFETLHWKLE 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	38/100 (38%)
		PTKc_Csk_like	793..1047	CDD:270635	111/264 (42%)
		STYKc	800..1044	CDD:214568	107/254 (42%)
Frk	NP_001153016.1	SH3_Src_like	54..111	CDD:212779	13/57 (23%)
		SH2_Src_Frk	119..214	CDD:199831	35/94 (37%)
		PTKc_Frk_like	232..501	CDD:270653	112/267 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820