Protein Alignment Csk and Fgfr4

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_006517162.3
• Gene: Fgfr4 / 14186
• MGIID: 95525
• Length: 829
• Species: Mus musculus
• Alignment Length: 692
• Identity: 180/692 - (26%)
• Similarity: 283/692 - (40%)
• Gaps: 163/692 - (23%)

  Fly   425 SQSQPHIVPPSIPPHHHHHR-ENNVHPIQAG--------AAA----ALH--LSSHALNSHNLISS 474
            |.|..|:.|...|...|..| |..:|.:.||        ||.    .:|  ....|.:..|.|..
Mouse   162 SSSSGHVYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKDGQAFHGENRIGG 226

  Fly   475 A----SNHSPKSPSQTQQQQQTTNQQQQQQQQQASHS----ILSTFAPAPTVAAVQPAGSQSVAG 531
            .    .:.|....|.....:.|.....:.......:|    :|......|.:.|..||.:.:|.|
Mouse   227 IRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVG 291

  Fly   532 TAAAVAAVAQQQQQQHLQLLANCPPGGAGLMSSSLNAAQMGMHGAERALPPKSLALSGSQHGSN- 595
            :...:........|.|:|.|                               |.:.::||..|::
Mouse   292 SDVELLCKVYSDAQPHIQWL-------------------------------KHVVINGSSFGADG 325

  Fly   596 ----MLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGS--GVNASSAWSSGSTT 654
                .:|.|........:...:..||.. .||..|.|         ||:  |::..|||    .|
Mouse   326 FPYVQVLKTTDINSSEVEVLYLRNVSAE-DAGEYTCL---------AGNSIGLSYQSAW----LT 376

  Fly   655 AMNHASLSPTALAPQ----------QGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVR 709
            .:....|:.|...|:          .|.....|.|.....:|..:.|  ..:..||     ..::
Mouse   377 VLPEEDLTWTTATPEARYTDIILYVSGSLVLLVLLLLAGVYHRQVIR--GHYSRQP-----VTIQ 434

  Fly   710 ESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADADG--LCTQLIKC 772
            :.:.||                    |..:.:::.....::...||......:.|  |.|.|:..
Mouse   435 KLSRFP--------------------LARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVNL 479

  Fly   773 -LPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGIL---------RNEKVAVK 827
             ||              :|..|..|...|.|.:.:|:|.||.|:....         :...||||
Mouse   480 DLP--------------LDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVK 530

  Fly   828 MLKDEGA---VQKFLAEASVMTTL-EHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSR--- 885
            ||||..:   :...::|..||..: .|.|::..:|:......||::.|..:||:|.::||:|
Mouse   531 MLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPP 595

  Fly   886 -----------GRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGL 939
                       ....::....:..||..|.||:|||::|.:||||||||||::||.|.|::||||
Mouse   596 GPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGL 660

  Fly   940 AREECYNLDV------GKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLAD 998
            || ..:::|.      |:||:||.|||||.:..::::||:||||||||||::.|..|||.||:.:
Mouse   661 AR-GVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEE 724

  Fly   999 VVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL 1040
            :...:..|::||.|..||.|:|.:||:.|...|::||||.:|
Mouse   725 LFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQL 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	15/99 (15%)
		PTKc_Csk_like	793..1047	CDD:270635	107/281 (38%)
Fgfr4	XP_006517162.3	IG_like	70..143	CDD:214653
		Ig strand B	80..84	CDD:409353
		Ig strand E	111..115	CDD:409353
		Ig strand F	125..130	CDD:409353
		Ig	174..268	CDD:472250	17/93 (18%)
		Ig strand B	195..199	CDD:409353	0/3 (0%)
		Ig strand C	208..212	CDD:409353	1/3 (33%)
		Ig strand E	234..238	CDD:409353	1/3 (33%)
		Ig strand F	248..253	CDD:409353	1/4 (25%)
		Ig strand G	261..264	CDD:409353	0/2 (0%)
		Ig	276..378	CDD:472250	29/146 (20%)
		Ig strand B	294..298	CDD:409353	0/3 (0%)
		Ig strand C	307..311	CDD:409353	2/3 (67%)
		Ig strand E	343..347	CDD:409353	0/3 (0%)
		Ig strand F	357..362	CDD:409353	2/13 (15%)
		Ig strand G	370..373	CDD:409353	0/2 (0%)
		PTKc_FGFR4	481..794	CDD:133230	110/301 (37%)