DRSC/TRiP Functional Genomics Resources

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Protein Alignment Csk and Fgfr3

DIOPT Version :10

Sequence 1:NP_731611.2 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_001156689.1 Gene:Fgfr3 / 14184 MGIID:95524 Length:802 Species:Mus musculus


Alignment Length:748 Identity:196/748 - (26%)
Similarity:306/748 - (40%) Gaps:227/748 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   519 AAVQPAG-SQSVAGTAAAVAAVAQQQQQQ-------HLQLLANC-PPGGA------------GLM 562
            |..:|.| .|.|...||.|......||:|       .::|  :| |||||            ||:
Mouse    18 ATSEPPGPEQRVVRRAAEVPGPEPSQQEQVAFGSGDTVEL--SCHPPGGAPTGPTVWAKDGTGLV 80

  Fly   563 SSS-----------LNAA--QMGMHGAERALPPKSLA----------LSG-SQHGSNMLLHT-AP 602
            :|.           |||:  ..|::..:..|..:.|.          .|| .:.|.::...| ||
Mouse    81 ASHRILVGPQRLQVLNASHEDAGVYSCQHRLTRRVLCHFSVRVTDAPSSGDDEDGEDVAEDTGAP 145

  Fly   603 ---QPPQASQ-----PAAVV-----GVSGSGSAGMSTSLHSFDINGVTAGSGVN-ASSAWS---- 649
               :|.:..:     |||..     ..:|:.:..:|...:..:..|.....|:. ....||    
Mouse   146 YWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVME 210

  Fly   650 -----------------SGS---TTAMNHASLSP-------------TALAPQQGRSRCEVKLNA 681
                             .||   |..::....||             ||:........|:|..:|
Mouse   211 SVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAILGSDVEFHCKVYSDA 275

  Fly   682 MP----------------------------WFHGSITRDEAEHL--LQPREDGLFLVRESTNFPG 716
            .|                            |...::..|....|  :..|:.|.:|.| :|||.|
Mouse   276 QPHIQWLKHVEVNGSKVGPDGTPYVTVLKSWISENVEADARLRLANVSERDGGEYLCR-ATNFIG 339

  Fly   717 DYTLCVCFQSKVEHYRV---KYLENKLTIDDEE---YFENLGQLVAHY----EADADGLCTQLIK 771
                   ...|....||   :..|.:|...||.   |...|...|..:    ...|..||.  ::
Mouse   340 -------VAEKAFWLRVHGPQAAEEELMETDEAGSVYAGVLSYGVVFFLFILVVAAVILCR--LR 395

  Fly   772 CLPKLG--------------KQEFCINSKDFV------------------------------DKG 792
            ..||.|              |::..:.|...:                              |..
Mouse   396 SPPKKGLGSPTVHKVSRFPLKRQVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSELELPADPK 460

  Fly   793 WVIPEAELQLRESIGKGEFGDVM----LGILRNE-----KVAVKMLKDEGA---VQKFLAEASVM 845
            |.:....|.|.:.:|:|.||.|:    :||.::.     .||||||||:..   :...::|..:|
Mouse   461 WELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMM 525

  Fly   846 TTL-EHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSR--------------GRQHITKKDQ 895
            ..: :|.|::..:|.......||::.||.:||:|.::||:|              ..:.:|.||.
Mouse   526 KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDACRLPEEQLTCKDL 590

  Fly   896 IIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAREECYNLDV------GKLPI 954
            :..||..|.|||||.::|.:||||||||||::||.|.|::|||||| :.:|||.      |:||:
Mouse   591 VSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLAR-DVHNLDYYKKTTNGRLPV 654

  Fly   955 KWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEI 1019
            ||.|||||.:..::::||:||||:|||||::.|..|||.||:.::.|.::.|::|:.|..|..::
Mouse   655 KWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPASCTHDL 719

  Fly  1020 YEMMRQAWDLNPAKRPTFAELKVKLQLLNNATA 1052
            |.:||:.|...|::||||.:|...|..:...|:
Mouse   720 YMIMRECWHAVPSQRPTFKQLVEDLDRILTVTS 752

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CskNP_731611.2 SH2_csk_like 680..777 CDD:198190 28/136 (21%)
PTKc_Csk_like 793..1047 CDD:270635 111/286 (39%)
Fgfr3NP_001156689.1 ig 46..110 CDD:395002 15/65 (23%)
Ig strand B 55..59 CDD:409353 1/5 (20%)
Ig strand C 69..73 CDD:409353 0/3 (0%)
Ig strand E 91..94 CDD:409353 0/2 (0%)
Ig strand F 104..108 CDD:409353 0/3 (0%)
IgI_2_FGFR 145..239 CDD:409443 14/93 (15%)
Ig strand A 145..148 CDD:409443 1/2 (50%)
Ig strand A' 156..161 CDD:409443 0/4 (0%)
Ig strand B 165..173 CDD:409443 0/7 (0%)
Ig strand C 179..184 CDD:409443 1/4 (25%)
Ig strand C' 187..189 CDD:409443 0/1 (0%)
Ig strand D 198..201 CDD:409443 0/2 (0%)
Ig strand E 205..210 CDD:409443 2/4 (50%)
Ig strand F 219..226 CDD:409443 0/6 (0%)
Ig strand G 229..239 CDD:409443 3/9 (33%)
IgI_3_FGFR 247..347 CDD:409363 18/107 (17%)
Ig strand A 247..250 CDD:409363 0/2 (0%)
Ig strand A' 254..258 CDD:409363 0/3 (0%)
Ig strand B 266..273 CDD:409363 2/6 (33%)
Ig strand C 277..284 CDD:409363 1/6 (17%)
Ig strand D 299..304 CDD:409363 0/4 (0%)
Ig strand E 315..320 CDD:409363 0/4 (0%)
Ig strand F 328..336 CDD:409363 3/8 (38%)
Ig strand G 339..347 CDD:409363 2/14 (14%)
PTKc_FGFR3 455..788 CDD:173652 113/299 (38%)

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