Protein Alignment Csk and Fgfr1

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_034336.2
• Gene: Fgfr1 / 14182
• MGIID: 95522
• Length: 822
• Species: Mus musculus
• Alignment Length: 285
• Identity: 114/285 - (40%)
• Similarity: 177/285 - (62%)
• Gaps: 36/285 - (12%)

  Fly   790 DKGWVIPEAELQLRESIGKGEFGDVML----GILRNE-----KVAVKMLKDEGAVQK----FLAE 841
            |..|.:|...|.|.:.:|:|.||.|:|    |:.:::     ||||||||.: |.:|    .::|
Mouse   468 DPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD-ATEKDLSDLISE 531

  Fly   842 ASVMTTL-EHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSR--------------GRQHIT 891
            ..:|..: :|.|::..:|.......||::.||.|||:|.:||::|              ..:.::
Mouse   532 MEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLS 596

  Fly   892 KKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAREECYNLDV------G 950
            .||.:..||..|.|||||.:||.:||||||||||::||.|.|::|||||| :.:::|.      |
Mouse   597 SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLAR-DIHHIDYYKKTTNG 660

  Fly   951 KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGC 1015
            :||:||.|||||.:..::::||:||||:|||||::.|..|||.:|:.::.|.::.|::|:.|..|
Mouse   661 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNC 725

  Fly  1016 PPEIYEMMRQAWDLNPAKRPTFAEL 1040
            ..|:|.|||..|...|::||||.:|
Mouse   726 TNELYMMMRDCWHAVPSQRPTFKQL 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190
		PTKc_Csk_like	793..1047	CDD:270635	113/282 (40%)
Fgfr1	NP_034336.2	IgI_1_FGFR	25..118	CDD:409362
		Ig strand A	25..28	CDD:409362
		Ig strand A'	40..46	CDD:409362
		Ig strand B	49..59	CDD:409362
		Ig strand C	63..68	CDD:409362
		Ig strand C'	71..73	CDD:409362
		Ig strand D	78..82	CDD:409362
		Ig strand E	85..90	CDD:409362
		Ig strand F	96..105	CDD:409362
		Ig strand G	108..118	CDD:409362
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..162
		IgI_2_FGFR	153..247	CDD:409443
		Ig strand A	153..156	CDD:409443
		Heparin-binding	160..177
		Ig strand A'	164..169	CDD:409443
		Ig strand B	173..181	CDD:409443
		Ig strand C	187..192	CDD:409443
		Ig strand C'	195..197	CDD:409443
		Ig strand D	206..209	CDD:409443
		Ig strand E	213..218	CDD:409443
		Ig strand F	227..234	CDD:409443
		Ig strand G	237..247	CDD:409443
		Ig	255..359	CDD:472250
		Ig strand B	273..277	CDD:409353
		Ig strand C	286..290	CDD:409353
		Ig strand E	324..328	CDD:409353
		Ig strand F	338..343	CDD:409353
		Ig strand G	351..354	CDD:409353
		PTKc_FGFR1	464..765	CDD:270678	114/285 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	782..822