Protein Alignment Csk and M176.9

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001305207.1
• Gene: M176.9 / 13186458
• WormBaseID: WBGene00014813
• Length: 543
• Species: Caenorhabditis elegans
• Alignment Length: 554
• Identity: 131/554 - (23%)
• Similarity: 222/554 - (40%)
• Gaps: 128/554 - (23%)

  Fly   590 SQHGSNMLLHTAPQPPQASQ-----PAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNASSAWS 649
            |:...:..|:...:|.:...     ||||    .||.:..|:.|.:.|  |..|||..:......
 Worm     3 SKDARSFALYVNSKPNKTKSTSKMIPAAV----ASGRSRRSSMLPTTD--GPVAGSRRDKLERSK 61

  Fly   650 SGSTTAMN-HASLSPTALAPQQGRSR-------C-------------------EVKLNAMPWFHG 687
            .|:..... .|:|.||..:.:...||       |                   |..|....::||
 Worm    62 RGTRDRERPEATLQPTEKSARGKSSRRKKKKPQCTAPEEKSLMTSDREYFPVLEKTLRGFKFYHG 126

  Fly   688 SITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVC--------------------------FQS 726
            .:          ||||    ::.:.:.||||.:.|.                          .:.
 Worm   127 FL----------PRED----LQATLHNPGDYLIRVSEVVEGESKVVREIILSLMTGHMEGKQKEK 177

  Fly   727 KVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDK 791
            ::.:..:|.:.||...:....|..:..|:.:|.... |.|:.        |..:.   ....:.:
 Worm   178 RIHNVVIKRVSNKFFCEAARPFATVADLINYYTKHT-GHCSS--------GNFQL---KHPILQQ 230

  Fly   792 GWVIPEAELQLRESIGKGEFGDVMLGILR-----NEKVAVKMLK-----DEGAVQKFLAEASVMT 846
            .|....:::.:.:.:|:|.||.|..|.||     :.:||:||.|     .:..:::.:.||..:.
 Worm   231 TWEFMHSDVTVGDVLGEGAFGKVCAGELRLKDGSSAEVAIKMTKASAFLSKMKIKEMMNEARFIR 295

  Fly   847 TLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEA 911
            ...|.|:|:..|:....:.||::.|.:..|||.||::.  .:.:...|:|.|....|.|:.||..
 Worm   296 NFNHKNVVRLYGVAHDEQPLYILLELVKGGSLQDYMKQ--TKSVPLADRINFCLGAAKGLAYLHQ 358

  Fly   912 KKVVHRDLAARNVLISEDCVAKVSDFGLARE-ECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMW 974
            ...:|||:||||.|:.|:.| |::||||:|. ..|..... |:||||.|||.|....||..:|::
 Worm   359 NNCIHRDIAARNCLLHENEV-KITDFGLSRAGPSYTTKTSCKIPIKWLAPETLATLSFSYATDVY 422

  Fly   975 SFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPT--- 1036
            |:|:..:|::..|..|:..:..|.:...:........|...|.|:.|.|.....:..::|.|
 Worm   423 SWGVTCYEVFVDGAEPFEGVSNATIKADIMANNFYPMPSMTPDEVKEYMSSCIFVEESRRATIPL 487

  Fly  1037 -------FAEL---------KVKLQLL----NNA 1050
                   ||.:         |.|.:||    ||:
 Worm   488 AVAEFERFARMCEDGTLQMGKAKNRLLAVFKNNS 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	19/122 (16%)
		PTKc_Csk_like	793..1047	CDD:270635	81/284 (29%)
M176.9	NP_001305207.1	SH2_Fps_family	116..212	CDD:198224	18/109 (17%)
		PTKc	243..493	CDD:270623	76/252 (30%)