Protein Alignment Csk and hop

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_317101.4
• Gene: hop / 1277627
• VectorBaseID: AGAMI1_008510
• Length: 1149
• Species: Anopheles gambiae
• Alignment Length: 1060
• Identity: 243/1060 - (22%)
• Similarity: 397/1060 - (37%)
• Gaps: 286/1060 - (26%)

  Fly   109 SREAAAAATLSGSGLTRSASSVTHKEAST-------------HATHTGGQVISRARRKPILLCSS 160
            |||.....: :|.||.|   ::.|::|:|             |.|:. .::::       :|...
Mosquito   247 SRETTKYGS-TGGGLER---TLDHEDATTTPGLKVFYASKWQHVTNI-DEILT-------ILVEK 299

  Fly   161 LSAAYAPPRRREFYFCDKYAPGPARSTPTTTT---------TSATSAKHESSPPIDARLLNFLRC 216
            |:...|...:.|.|..|.:......|..|...         |......:.|||.::  ||..|:|
Mosquito   300 LTVKLALEDQSEPYCIDFHDQTELNSFVTCLAGYYRLMCKWTVYLCQDYLSSPMLN--LLKELKC 362

  Fly   217 AH----RKFQASKAKTE--------LQQTKDRFLGNSRERTSKNGQQTSRSLPPIASSEEWF--- 266
             |    .|:...|.:.:        ::|.::::.....:....:|...:..|  |.:.::|.
Mosquito   363 -HGPIGGKYSTDKIREKNSSCGACIIRQCEEQYDTYYVDMLETDGLIKTYKL--IHAEDQWHVQR 424

  Fly   267 ---DEEAQAR---KTSHEKSQKP------KPKPEENHKEKEAI----SRKASGEGDLITVEIKQG 315
               :|||..|   .|...||..|      :..|.:|......:    :.|||          .:.
Mosquito   425 DKEEEEALHRYNQLTEALKSLNPEITSVYRLPPSDNDTAPNLLLCRPTHKAS----------PKR 479

  Fly   316 LLRKQTATTTTGQAMNSHATATQNGQTTVVGHHRGFSQPSVTVAAAAATGSTAGDPWFLQTTGHQ 380
            |||..|      |.:........|....:|     .::.:|...:...|..|..|  ||.....:
Mosquito   480 LLRGGT------QELGQKRACIINAAKELV-----INRNAVEDESDGYTKRTRAD--FLLPNNSK 531

  Fly   381 MPPTAPLRHNKRPAPQPNAVLG-AGSSGTAPGSAVGAVLLHQQQLSQSQPHIVPPSIPPHHH--- 441
            |..|..|..|::........|. ||...|.  .::..:.|:  .::..:|..:....|.:..
Mosquito   532 MEVTLKLLKNEKEGEYLKDFLQVAGQWATI--DSIDIIKLY--GMTVCKPITMVLEFPRYGRLDE 592

  Fly   442 --HHRENNVHP---IQAGAAAALHLSSHALNSHNLISSASNHSPKSPSQTQQQQQTT-----NQQ 496
              ..|..:|.|   |:.|.:.|..|  :.|..|.:|......|....:|..:.:|..     :..
Mosquito   593 FLRTRRTSVRPTALIEIGHSLARAL--YYLQKHGIIHGHIRCSSMLVTQYDEGEQRVLAKLGDPG 655

  Fly   497 QQQQQQQASHSILSTFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGGAGL 561
            ...|::...|.:|  :.|    ...|....||||                  :|.|: |...|..
Mosquito   656 MHGQRRLTKHDLL--WIP----YEYQDLSEQSVA------------------RLRAD-PATDAWA 695

  Fly   562 MSSSL-----NAAQMGMHGAERALP--------PKSL--------ALSGSQHGSNMLLHTAPQPP 605
            .:|:|     ...:|.::.....||        |..|        .||...|.         .|.
Mosquito   696 CTSTLWEIFSRGIKMHVYKPAEFLPTRKWLQTMPPELKDSKQIYECLSCGWHA---------DPD 751

  Fly   606 QASQPAAVVGVSGSGSAGMSTSLHSFDING--VTAGSG-VNASSAWSSGSTTAMNHASLSPTALA 667
            :...|..|||:          .:|:..::|  .|.|:| ||..      ||:.|.:.|:
Mosquito   752 KRLAPQTVVGL----------LVHARQLDGSYCTVGNGHVNGH------STSNMLNGSV------ 794

  Fly   668 PQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYR 732
                             |..||...|....         |:|..|:         |..|
Mosquito   795 -----------------FKNSILSMETNST---------LIRSRTD---------CTSS------ 818

  Fly   733 VKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPE 797
             .|:.|.   .|.|...|.          :.|..:     ||.|.......:...:.:|.:|...
Mosquito   819 -SYVSNG---SDSELRSNA----------SSGSSS-----LPLLSNSVNRFSGDSYYEKTFVNCS 864

  Fly   798 AELQLRES--------IGKGEFGDVMLGILRNEK-----VAVKMLKDE----GAVQ-KFLAEASV 844
            ..:||..|        :|:|.:|.|..|.|..:.     ||:|.:.|:    |.|: .|..|..:
Mosquito   865 DYIQLSGSERIFFHNMLGEGNYGRVYRGTLERDNQAPRDVALKTIYDDRPDLGRVKDDFRREVDI 929

  Fly   845 MTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYL 909
            |..|.|.|:|:||..:.....|.:|.||:..|||:.|| ...|..:.:.|.:..|.|.|:||.||
Mosquito   930 MKNLRHTNIVEFICFIEELDKLVVVMEYVPLGSLLAYL-GYMRYELKELDLLWMARDIANGMNYL 993

  Fly   910 EAKKVVHRDLAARNVLI-SEDCVAKVSDFGLAR-EECYNLDVGK----LPIKWTAPEALKNGRFS 968
            ..|.:|||||||||:|: |:.|| |:||||||: .|..|..|.:    |||:|.|||.|:..::|
Mosquito   994 CEKNIVHRDLAARNILVESKKCV-KISDFGLAQVTEGSNYYVARHSRELPIRWYAPETLETQKYS 1057

  Fly   969 NKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYK----MEAPEGCPPEIYEMMRQAWDL 1029
            ::||:||||:.|:|::::|..||..:.:....:..::..:    ::.||.......::|...:..
Mosquito  1058 SQSDVWSFGVTLYEMFTYGATPYSHVDVKSAAQLYQLLQRETKILQLPEDFSYVYDKLMAPCFKR 1122

  Fly  1030 NPAKRPTFAELKVKLQLLNN 1049
            :|.:|.||:||   |:.||:
Mosquito  1123 DPHERMTFSEL---LEELND 1139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	17/96 (18%)
		PTKc_Csk_like	793..1047	CDD:270635	97/281 (35%)
hop	XP_317101.4	None