Protein Alignment Csk and LOC1274321

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_061504086.1
• Gene: LOC1274321 / 1274321
• VectorBaseID: AGAMI1_010576
• Length: 1601
• Species: Anopheles gambiae
• Alignment Length: 1241
• Identity: 294/1241 - (23%)
• Similarity: 468/1241 - (37%)
• Gaps: 360/1241 - (29%)

  Fly    22 PTPS-PSGADATVSSSLERVLKP-----ASASASPSNSNNES--------DNSQTSSGSQTASSA 72
            ||.| .|.||.|..|....|..|     .:.|...:|:::||        :..|.:||.....||
Mosquito   486 PTVSGSSSADKTPRSGPTPVQTPKPGHRGATSTVTTNADSESVCSFVVCRERVQAASGDVLPPSA 550

  Fly    73 SKRSNRSVGRSHRGSIAQ------DTRRRYYFGSKDIYWC-------KQS-----------REAA 113
            |..:.|....:...:.|:      |:.:|......|:..|       :||           |:..
Mosquito   551 SDPTIRPAEPADGATYAELLPARNDSDQRLSNVYVDMEACLLHELDVEQSFQYTNLSSCGPRQQP 615

  Fly   114 AAATLSGSGLTRSAS------------SVTHKEASTHATHTGGQVISRARRKPILLCSSLSAAYA 166
            ..|:.:|.....|..            ::.::...|||:....:|....|:.|   |   .||..
Mosquito   616 LVASAAGESFGASCELPNPTNTDHQRHALQYRRLRTHASSEDSEVHLLNRQYP---C---EAADE 674

  Fly   167 PPRRREFYFCDKYAPGPARSTPTTTTTSATS--AKHESSPPIDARLLNFLRCAHRKFQASKAKTE 229
            |....:....|   .|.||.|.......:.:  .:.||......:.|:......||      .||
Mosquito   675 PGAGEDDEDDD---DGAARCTNADELNDSKNNLLREESFDENQRQQLSNCSTWRRK------STE 730

  Fly   230 LQQTKDRFLGNSRERT--------SKNGQQTS---RSLPPIASSEEWFDEEAQ-ARKTSHE---- 278
            ..:|..::|...:|..        |:..|..|   |.|..|.:..:..||..: |.:.|.|
Mosquito   731 EGETDGKYLTMRKEVAIPAPEAIPSQEAQWKSSIERHLDHIDALNQKLDEHQRLAARLSEEYEYI 795

  Fly   279 ------------KSQKPKP---KP-----EENHKEKEAISRKASGEGDLITVEIKQGLLRKQTAT 323
                        :.|||.|   ||     |:.:..:|.|.|:..|              .||.:.
Mosquito   796 RVQTLTRPAVAPQPQKPLPGATKPPTQTFEKANSFREKIRRRIKG--------------TKQDSD 846

  Fly   324 TTTGQAM---NSHATATQNG--QTTVVGHH--RGFSQPSVTVAAAAATGSTAGDPWFLQTTGHQM 381
            ....:::   |.....:.:|  ::.:..||  |.|.....|.:|:.:|.         ::...::
Mosquito   847 RQADRSVSPDNPDQPESFSGRLRSRITAHHTQRQFRLMKDTDSASPSTD---------RSIAERL 902

  Fly   382 PP---TAPLRHNKRPAPQPNAVLGAGSSGTAPGSAVGAVLLHQQQLSQSQPHIVPPSIPPHHHHH 443
            ||   .|..:..||.|.:.|...                   :||||:..        |..|...
Mosquito   903 PPGNSAAGRKKKKRKASKANRAA-------------------RQQLSRGG--------PDGHQPE 940

  Fly   444 RENNVHPIQAGAAAALHLSSHALNSHNLISSASNHSPKSPSQTQQQQQTTNQQQQQQQQQASHSI 508
            |...:||                                       ||..::.:...::|.:.|.
Mosquito   941 RHQPLHP---------------------------------------QQAFSEDELLAEEQPALSP 966

  Fly   509 LSTFAPAPTVA-AVQPAGSQSVAGT-------------AAAVAAVAQQQQQQHLQLLANCPPGGA 559
            ..:..|..|.| .:..:.||:|..|             ::...|:...:.::.|.|:| ..|...
Mosquito   967 DHSGGPRATAAGGLGTSFSQTVRATWRELIHSTNKVKDSSMNLALRSDRPEEKLDLIA-ADPDRQ 1030

  Fly   560 GLMSSSLNAAQMG-------------MHGAERALPPKSLALS-------GSQHGSNMLLHTAPQP 604
            ||:|.....:..|             ||.......|..:|.|       ||..|.     ..|:.
Mosquito  1031 GLLSIRFTFSDGGRKHQLVDGMMASDMHTTADYCVPLLVARSEDTQLQAGSPDGD-----MRPET 1090

  Fly   605 PQASQPAAVVG-------------------VSG----SGSAGMST--------SLHSFDINGVTA 638
            |..:|.|:..|                   .||    ||...::|        |......:|...
Mosquito  1091 PVFAQRASKAGPSLKSNLRDKLTKLVHKKTASGGSVQSGGRSVATAQEVCRTCSKRIVQRSGSDG 1155

  Fly   639 GSGVNASSA-------------------WSSGSTTAM--------------NHASLSPTA----- 665
            |.|::||..                   ...|:|:.|              .|..:.|:|
Mosquito  1156 GGGMHASRTVLDFRKEFPDIDICEGGHDHLDGATSEMINLEYEDIDVLTIKPHKLIDPSAAEGGI 1220

  Fly   666 -LAPQQGRSRCEVKLNAMPWFHGSITRDEAEHLLQPREDGLFLVREST-NFPGDYTLCVCF---- 724
             ::.....:|   .|:...||||.:.|:|...||  |.:|.|||||:| |......|.||:
Mosquito  1221 CVSMTLSTNR---PLHEEEWFHGVLPREEVVRLL--RNEGDFLVRETTRNDESQTVLSVCWNGHK 1280

  Fly   725 ----QSKVE-HYRVKYLENKLTIDDEEYFENLGQLVAH-YEADADGLCTQLIKCLPKLGKQEFCI 783
                |:..| |||.          :...|.::.:|:.| |:::           ||..|:.. .:
Mosquito  1281 HFIVQTTAEGHYRF----------EGPAFPSIQELIVHQYQSE-----------LPVTGRSG-AV 1323

  Fly   784 NSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNEK---VAVK---MLKDEGAVQKFLAEA 842
            ..|..:.:.|.:...::.|.:.||:|.||||....|::.|   ||||   |...|...:|||.|.
Mosquito  1324 LRKPVLRERWELSNDDVILLDKIGRGNFGDVYKAKLKSSKNTLVAVKTCRMTLPEEQKRKFLQEG 1388

  Fly   843 SVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGME 907
            .::...:|.|:||.||:....:.:.:|.|.::.|||:.:|| :....:.::..:....|.|:||.
Mosquito  1389 RILKQYDHPNIVKLIGICVQKQPIMIVMELVAGGSLLMFLR-KNASTLGQRQMMGMCRDAAAGMR 1452

  Fly   908 YLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAREECYNLDVG---KLPIKWTAPEALKNGRFSN 969
            |||:|..:||||||||.||..:.:.|:||||::|||...:..|   ::||||||||||..|::::
Mosquito  1453 YLESKNCIHRDLAARNCLIGSENIVKISDFGMSREEEEYIVSGGMKQIPIKWTAPEALNFGKYTS 1517

  Fly   970 KSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKR 1034
            ..|:||:|||:|||:|.|..||..:..:...:.::.||:|.||||.|||:|.:|.:.|...|..|
Mosquito  1518 LCDVWSYGILVWEIFSRGDTPYSGMSNSMARERIDEGYRMPAPEGAPPEMYRLMLKCWSYEPESR 1582

  Fly  1035 PTFAEL 1040
            |.|.|:
Mosquito  1583 PHFDEI 1588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	31/107 (29%)
		PTKc_Csk_like	793..1047	CDD:270635	103/257 (40%)
LOC1274321	XP_061504086.1	None