Protein Alignment Csk and Shark

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_061517294.1
• Gene: Shark / 1272509
• VectorBaseID: AGAMI1_002383
• Length: 1207
• Species: Anopheles gambiae
• Alignment Length: 869
• Identity: 207/869 - (23%)
• Similarity: 323/869 - (37%)
• Gaps: 273/869 - (31%)

  Fly   283 PKPK-------PEENHKEKE-------------AISRKASGEGDLITVEIKQGLLRKQTATTTTG 327
            |||.       |:..|:...             :.....:|.|.|:|..: ..:.||.:...||
Mosquito   428 PKPPIPAFATIPKSKHRMHRTDGTTAALPSYGGSAHHSTNGSGSLLTAGL-TSMFRKSSENPTT- 490

  Fly   328 QAMNSHATAT--QNGQTTVVGHHRGFSQPSVTVAAAAATGSTAGDPWFLQTTGHQMPPTAPLRHN 390
                  ||||  ..|..:     |..|.|:..:......|.....|       .:..|..|.|::
Mosquito   491 ------ATATLPSKGMPS-----RNLSVPNDAMLQMNRVGLFDRSP-------ERCAPETPRRNS 537

  Fly   391 KRPAPQPNA-------VLGAGSSGTAPGSAVGAVLLHQQQLSQSQPHIVPPSIPPHHHHHRENNV 448
            |.|. .||.       ..|:.:|.|...:.:..:    :.|.:|:..:.|.:..|
Mosquito   538 KGPT-SPNTPDEPKTKPSGSNASPTLKKTLMDGM----KSLRKSKQKLKPAAADP---------- 587

  Fly   449 HPIQAGAAAALHLSSHALNSHNLISSASNHSPK-SPSQTQQQQQTTNQQQQQQQQQASHSILSTF 512
               ..|:....:.||.:||       .|:..|. |||:..||.:.:          :..:::::.
Mosquito   588 ---DGGSGTETNSSSASLN-------VSSIEPTVSPSKLLQQLKFS----------SDFNLVASC 632

  Fly   513 APAPTVAAVQPAGSQSVA----GTAAAVAAVAQQQQQQHLQLLANCPPGGAGLMSSSLNAAQMGM 573
            |.|..:..: |..:.::.    |....||..|          |:..|| .|||...|
Mosquito   633 AAADDIYKI-PTNNCAIVDIDIGEPPVVAVPA----------LSTSPP-VAGLQDDS-------- 677

  Fly   574 HGAERALPPK-SLALSGSQH-----------------------------GSNMLLHTAPQPPQAS 608
             ....|:||| |..|..|.:                             |.::....||.||.|.
Mosquito   678 -ELPPAIPPKLSAPLLDSVNNNNNNESATLDYFTQSDDPLRSDTLPDDAGEDIYFVEAPIPPPAR 741

  Fly   609 QPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRS 673
              |.:...:.:|.|.:        :|              ::.:.|..:.|::.|...||..
Mosquito   742 --ACLEAAAAAGGASL--------LN--------------NNNTVTPDDPAAIQPARNAPTN--- 779

  Fly   674 RCEVKLNAMPWFHGSITRDEAEHLLQP------REDGLF--LVRESTNF------PGDYTLCVCF 724
              .:....:|.| .|::.:|.:....|      |...||  |....::|      .|:......|
Mosquito   780 --YIMTKTVPIF-SSVSVEECQTPTSPTCGGQMRASKLFERLDSNQSSFSRASVLSGESVFFAMF 841

  Fly   725 QSKVEHYRVKYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFV 789
            |.                          |..::..|..:|
Mosquito   842 QQ--------------------------QQSSNTAAQPEG------------------------- 855

  Fly   790 DKGWVIPEAELQLRESIGKGEFGDVMLGIL---------------------------RNEKVAVK 827
             ..:.||:..:.....:|:||||.|..|.|                           ....||:|
Mosquito   856 -PNYFIPKECIHAETVLGRGEFGFVYQGFLDPWPVDIAGGGYQSGGVAHKTSPPVMMGRVPVAIK 919

  Fly   828 MLKDEGAVQ---KFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQH 889
            .:.|....:   .||.|||||..|.|:.:|:.|| :.....|.:|.|.:|.||::.|:.......
Mosquito   920 KVMDSQERRDRTDFLREASVMIRLRHNCIVRLIG-ICKGPPLIMVQELISLGSMLVYITKNKATI 983

  Fly   890 ITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR-----EECYNLDV 949
            ..|::.:|:|...||||:|||.|..|||||||||:|::....||:|||||:|     :|.|....
Mosquito   984 NPKQEMMIWAAQIASGMQYLEEKHFVHRDLAARNILLANKYQAKISDFGLSRAIGAGQEYYRASQ 1048

  Fly   950 -GKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPE 1013
             ||.||||.|||:...|.||:.||:||||:.|||::|:|..||..:..|:|:|.:|...::..|:
Mosquito  1049 GGKWPIKWYAPESFNYGTFSHASDVWSFGVTLWEMFSYGAPPYHDMKGAEVIKLIEEDQRLSRPD 1113

  Fly  1014 GCPPEIYEMMRQAWDLNPAKRPTF 1037
            .||.:::|:||..|..||..||||
Mosquito  1114 ACPDKVFEVMRNCWQYNPKLRPTF 1137

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	16/110 (15%)
		PTKc_Csk_like	793..1047	CDD:270635	106/281 (38%)
Shark	XP_061517294.1	None