Protein Alignment Csk and sev

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_061503032.1
• Gene: sev / 1272261
• VectorBaseID: AGAMI1_009976
• Length: 2555
• Species: Anopheles gambiae
• Alignment Length: 1225
• Identity: 253/1225 - (20%)
• Similarity: 416/1225 - (33%)
• Gaps: 394/1225 - (32%)

  Fly     4 TIKITCDGVFIQSNSYLMPTPSPSGADATV---------SSSLERVLKPASASASPS-------- 51
            |:......|:::|.       :|||..:|:         |...:.|.:..|..|.|:
Mosquito  1355 TVDWVARAVYVRSQ-------TPSGNGSTLHAYDLNRFESGGSDPVHRMVSLPAEPAVIDLLQVR 1412

  Fly    52 ------------------NSNNESDNSQTSSGSQTASSASKRSNRSVGR-------SHRGSIAQD 91
                              .|.:|.|...|..........::.:.|..|.       ..:..|.||
Mosquito  1413 PGVAELVAVSRYARAGYIVSLDEPDREPTPFNCSGEDVENEWNQRLCGEYDGVFDVDGQHGIVQD 1477

  Fly    92 TRRRYYFGSKDIYWCKQSREAAAAATLSGSGLTRSASSVTHKEASTHATHTGGQVISRARRKPIL 156
            ....|:.|..|                 |:...|:.......:|:|......|.|        :|
Mosquito  1478 EGYLYWIGPDD-----------------GTVSVRARDGAPTSDATTQQFPLTGAV--------VL 1517

  Fly   157 LCSSLSAAYAPPRRREFYFC-------DKYAPGPARSTPTTTTTSATSAKH----ESSPP-IDAR 209
            |......||.|.|      |       .:|.|....:|.::.|......:.    |..|| :..|
Mosquito  1518 LPVQHRQAYPPER------CLVPVVQQIQYLPELYNNTESSITLRLPEPERHTDCERRPPAVRYR 1576

  Fly   210 LLNFLRCAHRKFQASKAKTEL----QQTKDRFLGNSR----------------------ERTSKN 248
            :|        ..|..:|..:|    .....|.:||.|                      :|....
Mosquito  1577 IL--------YQQEDEASADLHIDYSYESSRTIGNLRPFTNYRFGVVLTSYYLAAATTAQRLLVG 1633

  Fly   249 GQQT-----SRSLP-------------------PIASSE---EWFDEEAQARKTSHEKSQKP-KP 285
            |:.:     .||:|                   |::.:|   .|....   :|.||....:. :.
Mosquito  1634 GEPSITELPKRSMPVVFRTAVGPPSRPEDITAWPVSPTEAIVSWIPSR---QKNSHHVWYEIWRA 1695

  Fly   286 KPEENHKEKEAISRKASGEGDLITVEIKQGLLRKQTATTTTGQAMNSHATATQNG---QTTVVGH 347
            :|:|:...::.:......:...:||||.: |...||.........|.||.:..:.   ||
Mosquito  1696 EPDEHKNRQQQVVTDFKMDDTSMTVEITR-LQPNQTYIVWVRAYSNFHAYSDSDKFQIQT----- 1754

  Fly   348 HRGFSQPS-VTVAAAAATGSTAGDPWFLQTTGHQMPPTAPLRHNKRPAPQPNAVLGAGSSGTAPG 411
               |.:|| :.:.:..:||...  .|        :||.     |.:......|::|..:..|
Mosquito  1755 ---FPEPSDIQLLSLNSTGIRL--RW--------IPPV-----NCQKYKIQYAIVGQSTWTT--- 1798

  Fly   412 SAVGAVLLHQQQLSQSQPHIVPPSIPPHHHHHRENNVHP-IQAGAAAALHLSSHA-----LNSHN 470
                        :..||    .||...:::|:..|.:.| .:......||.....     ....:
Mosquito  1799 ------------MYDSQ----GPSTHWYNYHYELNGLMPKTRYQFVVLLHYPYRDEPYVWPRERD 1847

  Fly   471 LISSASNHSPKSPSQ---TQQQQQTTNQQQQQQQQQASHSILSTFAPAPTVAAVQPAGSQSVAGT 532
            :|...:...|.:|.:   |:.:|.......:..:...  :|:..:|
Mosquito  1848 IIFETAADKPAAPGRPIVTKLRQDVYKVSWEAAKDNG--AIIEEYA------------------- 1891

  Fly   533 AAAVAAVAQQQQQQHLQLLANCPPGGAGLMSSSLNAAQMGMHGAERALPPKSLALSGSQHGSNML 597
                           |::|.           |.||.|      |...|.|.....:|
Mosquito  1892 ---------------LEVLV-----------SQLNRA------ARFVLSPDDDTAAG-------- 1916

  Fly   598 LHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFDINGVTAGSGVNASSAWSSGSTTAMNHASLS 662
             ..||            ||.||........|.::|.......:|.:.  .|            :.
Mosquito  1917 -ELAP------------GVEGSNGTATVGELETYDERWSQVYNGTDV--YW------------II 1954

  Fly   663 PTALAPQQGRSRCEVKLNAMPWF-HGSITRDEAEHLLQPRE--------------------DGLF 706
            |...|.|:...|...: |:..|. :...:|.....|...|.                    ..:|
Mosquito  1955 PERHAIQRNLFRVRAR-NSYGWGPYSDESRPTGPELYVQRTIIYIATFVSTLGTIVVVVALTVIF 2018

  Fly   707 LVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTIDDEEYFENLGQL--------VAHYEADAD 763
            |:|::              .|::::::.....:|:  |.| ..||.:|        ..:....:.
Mosquito  2019 LIRQT--------------DKMKNFQMDPANARLS--DVE-LANLRELPRRGNFVQTTNILYSSG 2066

  Fly   764 GLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILR------NE 822
            .:....|..||::...:..:.|...                 :|.|.||:|..|:::      ..
Mosquito  2067 SMTDSEIALLPRIRLDQIFMASSSL-----------------LGSGAFGEVYEGVVKGVDGEAET 2114

  Fly   823 KVAVKMLKDEGA----VQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLR 883
            :||:|.|| :||    .|:||.||.:|:..:|.::.:.:|:...:..|.::.|.|..|.|:.|||
Mosquito  2115 RVAIKTLK-KGAKLHEKQEFLQEAQLMSNFKHKHITRLLGVCLEADALLIIMELMQGGDLLSYLR 2178

  Fly   884 SRGRQ------HITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLIS----EDCVAKVSDFG 938
             |.|.      .:|..|.|....|.|||..|||....||||||.||.|:|    .|.|.|:.|||
Mosquito  2179 -RSRSLPGQAARLTMLDLISMCQDVASGCRYLEEMHFVHRDLACRNCLVSSTDPRDRVVKIGDFG 2242

  Fly   939 LAREECYNLDV------GKLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLA 997
            ||| :.|..|.      |.||::|.:||:|.:|.|:::||:|:||:|||||.:.|..||......
Mosquito  2243 LAR-DIYKNDYYRKEGEGLLPVRWMSPESLVDGVFTSQSDIWAFGVLLWEIMTLGEQPYQAKNNV 2306

  Fly   998 DVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELKVKLQLLNNATA 1052
            :|:.||..|..::.|:.||.|:||:|:..|..:|.:||||......|:.|...|:
Mosquito  2307 EVLNHVREGGHLDRPKVCPNEMYELMKYCWKFSPEERPTFRYCLEVLRALRENTS 2361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	18/125 (14%)
		PTKc_Csk_like	793..1047	CDD:270635	102/279 (37%)
sev	XP_061503032.1	None