Protein Alignment Csk and Wsck

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_308798.5
• Gene: Wsck / 1270126
• VectorBaseID: AGAMI1_014555
• Length: 769
• Species: Anopheles gambiae
• Alignment Length: 777
• Identity: 164/777 - (21%)
• Similarity: 272/777 - (35%)
• Gaps: 203/777 - (26%)

  Fly   424 LSQSQPHIVPPSIPPHHHHHRENNVHPIQ--------AGAAAALHLSSH--------ALNSHNL- 471
            :|.::|.|.|||:..|.|..:..::..:.        |||....:...:        ||.:.:|
Mosquito     1 MSSARPAINPPSVVVHFHRWQSLSLCVLTLLSICGGLAGAEKRAYFGCYERDRFARLALTTEHLD 65

  Fly   472 --ISSASNHSPKSPSQTQQQQQTTNQQQQQQQQQASHSILSTFAPAPTVAAVQPAGSQSVAGTAA 534
              :.|.:|...:....:..:...||..|.:..:.....:.....|......|   .:|:|..|..
Mosquito    66 ECVDSCANSFHRYAELSGSRCSCTNTIQTRIVEDRECDLKCGKQPDANCGGV---NAQAVYETGI 127

  Fly   535 AVAA------VAQQQQQQHLQL------------------------------------------- 550
            .||.      :..:|::..:.:
Mosquito   128 DVAGPVRNLRIEGEQKEDTIAIRWDLPADDGVMVEEFEIVAEATRTYASFRIYPVRWSVHNTSTG 192

  Fly   551 --LANCPPG-------------GAGLMSSSLNAAQMGMHGAERALP--------------PKSLA 586
              |:|..||             |||..:|...:.::|....|...|              |:::.
Mosquito   193 FELSNLQPGTDYNITVVSVSARGAGGRASIAGSTEIGHPDPEPEEPIILRRFESTILIQIPRAVN 257

  Fly   587 LSGSQHGSNMLLH----------------TAPQPPQASQP---AAVVGVSGSGS----AGMSTSL 628
            .:|..:...:::|                |..|..:...|   ||.:.:....|    .|.....
Mosquito   258 DNGPVNYYRVVVHYVNSELIQQIDESQLGTFQQSKENKVPYYIAAELEMKDDESLQFTVGDGREY 322

  Fly   629 HSFDINGVTAGSGVNASSAWSSGSTTAMNH---ASLSPTALAPQQGRSRCEVKLNAMPWFHGSIT 690
            .|:....:||.:.|:.    |.|..:.:||   ...:.|.....|......|.|..:     .|.
Mosquito   323 RSYFNPPITARTHVHI----SIGVVSILNHVVKVRYATTTHEQHQYPDHHHVNLKTV-----EIE 378

  Fly   691 RDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCF----QSKVEHYRVKYLENKLTIDDEEYFENL 751
            |:|.            |:...|      |.|:.|    ...:..|  .||..|....:...|.:
Mosquito   379 RNET------------LIAILT------TACILFGVVLTGAIILY--VYLHFKTPAANTRPFGD- 422

  Fly   752 GQLVAHYEADADGLCTQLIK--CLPKLGKQE-FCINSKDFVD-----KGWVIPEAELQLRESIGK 808
                 |:|....|...::..  .:|.:.:|. |....:|.::     |........|.:...:|.
Mosquito   423 -----HHELTLQGPILEVENNGYMPDIYEQRGFEAELRDIIEGLEPAKNHARKYLSLDINRVLGS 482

  Fly   809 GEFGDVMLGILR-------NEKVAVKMLKD--EGAVQ-KFLAEASVMTTLE-HDNLVKFIGLVFT 862
            |::|||:||.|:       :....|.::.|  |...| .||.|...:|.|| |.|::.|.|:..|
Mosquito   483 GKYGDVLLGALQLSQEQDGDMPAQVHVITDDMESVDQIAFLNEFRRLTALEGHANVILFYGVCVT 547

  Fly   863 SKHLYLVTEYMSKGSLVDYLRSR------GRQHITKKDQII--FAYDTASGMEYLEAKKVVHRDL 919
            ....||:.|.|........|.:|      ..:..|..::|:  .......||::|....||.:.|
Mosquito   548 PDWCYLLFEQMQTTLKQTLLNARVPASANSVKFSTISEEIVVNILCLVCDGMQFLADSNVVSKKL 612

  Fly   920 AARNVLISEDCVAKVSDFG--LAREECYNLDVGKLPI---KWTAPEALKNGRFSNKSDMWSFGIL 979
            .||.|.::.....|||.||  |..|     |.|. ||   :|.|||.:|....|.|||:||||:|
Mosquito   613 CARTVYVNTKFEVKVSAFGPPLNAE-----DTGS-PIAISRWHAPEVIKFQNHSTKSDVWSFGLL 671

  Fly   980 LWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAELK 1041
            :||....|..||......::...:..|.|.|.|.....::|::....|||:.:.||:|.:|:
Mosquito   672 IWECCCLGATPYGTTTTDNLFAAIRAGQKPERPSFMYEDLYQLCLNCWDLDASDRPSFDDLR 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	17/102 (17%)
		PTKc_Csk_like	793..1047	CDD:270635	83/273 (30%)
Wsck	XP_308798.5	None