DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Csk and Btk

DIOPT Version :9

Sequence 1:NP_001262476.1 Gene:Csk / 41398 FlyBaseID:FBgn0262081 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_038510.2 Gene:Btk / 12229 MGIID:88216 Length:659 Species:Mus musculus


Alignment Length:400 Identity:133/400 - (33%)
Similarity:222/400 - (55%) Gaps:33/400 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   668 PQQGRSRCEVKLNAMPWFHGSITRDEAEHLL-QPREDGLFLVRESTNFPGDYTLCVCFQSK---- 727
            |....:..|..:....|:...:||.:||.|| |..::|.|:||:|:. .|.||:.|..:|.    
Mouse   265 PSNYITEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSK-AGKYTVSVFAKSTGEPQ 328

  Fly   728 --VEHYRV-KYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCINSKDFV 789
              :.||.| ...:::..:.::..|..:.:|:.:::.::.||.::|...:.|..|     |:....
Mouse   329 GVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNK-----NAPSTA 388

  Fly   790 DKG---WVIPEAELQLRESIGKGEFGDVMLGILRNE-KVAVKMLKDEGAV--QKFLAEASVMTTL 848
            ..|   |.|...:|...:.:|.|:||.|..|..|.: .||:||:: ||::  .:|:.||.||..|
Mouse   389 GLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIR-EGSMSEDEFIEEAKVMMNL 452

  Fly   849 EHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQII-FAYDTASGMEYLEAK 912
            .|:.||:..|:....:.::::||||:.|.|::|||.  .:|..:..|:: ...|....|||||:|
Mouse   453 SHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLRE--MRHRFQTQQLLEMCKDVCEAMEYLESK 515

  Fly   913 KVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEALKNGRFSNKSDM 973
            :.:||||||||.|:::..|.|||||||:|   ::.|...|| |.|::|:.||.|...:||:|||:
Mouse   516 QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDI 580

  Fly   974 WSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFA 1038
            |:||:|:|||||.|::||.|...::..:|:..|.::..|......:|.:|...|.....:||:| 
Mouse   581 WAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADERPSF- 644

  Fly  1039 ELKVKLQLLN 1048
                |:.|.|
Mouse   645 ----KILLSN 650

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CskNP_001262476.1 SH2_csk_like 680..777 CDD:198190 27/104 (26%)
PTKc_Csk_like 793..1047 CDD:270635 99/261 (38%)
STYKc 800..1044 CDD:214568 96/251 (38%)
BtkNP_038510.2 PH_Btk 6..166 CDD:269944
Inositol-(1,3,4,5)-tetrakisphosphate 1-binding. /evidence=ECO:0000250 12..24
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 171..210
SH3_BTK 217..271 CDD:212839 1/5 (20%)
SH2_Tec_Btk 274..378 CDD:198260 26/104 (25%)
PTKc_Btk_Bmx 397..652 CDD:173657 99/261 (38%)
Inhibitor-binding. /evidence=ECO:0000250 474..479 4/4 (100%)
CAV1-binding. /evidence=ECO:0000250 581..588 4/6 (67%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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