DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csk and Bmx

DIOPT Version :9

Sequence 1:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_033889.2	Gene:	Bmx / 12169	MGIID:	1101778	Length:	655	Species:	Mus musculus

Alignment Length:	404	Identity:	147/404 - (36%)
Similarity:	232/404 - (57%)	Gaps:	27/404 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   657 NHASLSPTALA---PQQGRSRCEVKLNAMPWFHGSITRDEAEHLL-QPREDGLFLVRESTNFPGD 717
            |.||.|.:.::   |:...|..|..|:|..||.|:|:|.::|.|| |..::|.|:||.|:.. |.
Mouse   246 NIASHSTSKMSWGFPESSSSEEEENLHAYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQM-GM 309

  Fly   718 YTLCVCFQS------KVEHYRV-KYLENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCL-P 774
            ||:.:..::      .|:||.| ...||||.:.:...|:::.:|:.:::.::.|:.|:|...: .
Mouse   310 YTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVST 374

  Fly   775 KLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNE-KVAVKMLKDEGAV--Q 836
            |..|....:.....:   |.:...|:.|.:.:|.|:||.|.||..:.: .|||||:| |||:  .
Mouse   375 KANKVPVSVALGSGI---WELKREEITLLKELGNGQFGVVQLGQWKGQYDVAVKMIK-EGAMSED 435

  Fly   837 KFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQII-FAY 900
            :|..||..|..|.|..||||.|:......:|:||||::.|.|::||:|.|:.  .:..|:: ..|
Mouse   436 EFFQEAQTMMKLSHPKLVKFYGVCSKKYPIYIVTEYITNGCLLNYLKSHGKG--LESCQLLEMCY 498

  Fly   901 DTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTAPEA 961
            |...||.:||:.:.:||||||||.|:..|...||||||:.|   ::.|...|| |.|:||:|||.
Mouse   499 DVCEGMAFLESHQFIHRDLAARNCLVDSDLSVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEV 563

  Fly   962 LKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQA 1026
            ....::|:|||:|:||||:||::|.|:.||.....::||..|..|:::..|:.....||::|...
Mouse   564 FHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSEVVVKVSQGHRLYRPQLASDTIYQIMYSC 628

  Fly  1027 WDLNPAKRPTFAEL 1040
            |...|.|||||.:|
Mouse   629 WHELPEKRPTFQQL 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	32/105 (30%)
		PTKc_Csk_like	793..1047	CDD:270635	106/256 (41%)
		STYKc	800..1044	CDD:214568	104/249 (42%)
Bmx	NP_033889.2	PH_Btk	25..151	CDD:269944
		PH	27..115	CDD:278594
		SH2_Tec_Bmx	269..374	CDD:198262	32/105 (30%)
		PKc_like	392..647	CDD:304357	105/254 (41%)
		Pkinase_Tyr	397..646	CDD:285015	104/249 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810