Protein Alignment Csk and Blk

DIOPT Version :10

• Sequence 1: NP_731611.2
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_031575.2
• Gene: Blk / 12143
• MGIID: 88169
• Length: 499
• Species: Mus musculus
• Alignment Length: 536
• Identity: 181/536 - (33%)
• Similarity: 271/536 - (50%)
• Gaps: 90/536 - (16%)

  Fly   560 GLMSSSLNAAQMG-------MHGAERALPPKSLALSGSQHGSNMLLHTAPQPPQA---SQPAAVV 614
            ||:||....::.|       :...::|.||....:        :..|.||..|..   .:...||
Mouse     2 GLLSSKRQVSEKGKGWSPVKIRTQDKAPPPLPPLV--------VFNHLAPPSPNQDPDEEERFVV 58

  Fly   615 GVSGSGSAGMSTSLHSFD---ING----VTAGSGV----NASSAWSSGSTTAMNHASLSPTALAP 668
            .:              ||   :|.    |..|..:    :....|.:.|........:....:||
Mouse    59 AL--------------FDYAAVNDRDLQVLKGEKLQVLRSTGDWWLARSLVTGREGYVPSNFVAP 109

  Fly   669 QQGRSRCEVKLNAMPWFHGSITRDEAE-HLLQP-REDGLFLVRESTNFPGDYTLCV---CFQSK- 727
            .:       .|....||..:|:|.:|| .||.| .:.|.||:|||.:..|.::|.|   ..|.:
Mouse   110 VE-------TLEVEKWFFRTISRKDAERQLLAPMNKAGSFLIRESESNKGAFSLSVKDITTQGEV 167

  Fly   728 VEHYRVKYLEN-------KLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEFCIN- 784
            |:||:::.|:|       ::|      |..|..||.||....||||.:|  .||       |:|
Mouse   168 VKHYKIRSLDNGGYYISPRIT------FPTLQALVQHYSKKGDGLCQKL--TLP-------CVNL 217

  Fly   785 --SKDFVDKGWVIPEAELQLRESIGKGEFGDVMLGILRNE-KVAVKMLKDEGAV--QKFLAEASV 844
              ...:....|.||...|:|...:|.|:||:|.:|..:|. |||:|.|| ||.:  :.||.||:|
Mouse   218 APKNLWAQDEWEIPRQSLKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLK-EGTMSPEAFLGEANV 281

  Fly   845 MTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYL 909
            |.||:|:.||:...:| |.:.:|:|||||::|.|:|:|::.....::....|..:...|.||.|:
Mouse   282 MKTLQHERLVRLYAVV-TREPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQVAEGMAYI 345

  Fly   910 EAKKVVHRDLAARNVLISEDCVAKVSDFGLAR--EECYNLDVG-KLPIKWTAPEALKNGRFSNKS 971
            |....:||||.|.|:|:||....|::||||||  :..|....| |.|||||||||:..|.|:.|:
Mouse   346 ERMNSIHRDLRAANILVSETLCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKA 410

  Fly   972 DMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIY-EMMRQAWDLNPAKRP 1035
            |:||||:||.||.::||||||.:...:|::.:|.||:|..||.||||:| :::.:.|...|.:||
Mouse   411 DVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHGYRMPCPETCPPELYNDIITECWRGRPEERP 475

  Fly  1036 TFAELKVKLQLLNNAT 1051
            ||..|:..|:....||
Mouse   476 TFEFLQSVLEDFYTAT 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Csk	NP_731611.2	SH2_csk_like	680..777	CDD:198190	38/109 (35%)
		PTKc_Csk_like	793..1047	CDD:270635	115/260 (44%)
Blk	NP_031575.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		8/31 (26%)
		SH3	56..109	CDD:473055	9/66 (14%)
		SH2_Src_Blk	114..213	CDD:198234	36/106 (34%)
		Protein Kinases, catalytic domain	227..490	CDD:473864	115/264 (44%)